NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

CATALYTIC ACTIVITY: D-arabinono-1,4-lactone + O₂ = D-erythro-ascorbate + H₂O₂.
COFACTOR: FAD (By similarity).
PATHWAY: Cofactor biosynthesis; D-erythroascorbic acid biosynthesis; D-erythro-ascorbic acid from D-arabinose: step 2/2 .
SUBCELLULAR LOCATION: Mitochondrion membrane (By similarity). Note=Membrane-embedded (By similarity).
SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
SIMILARITY: Contains 1 FAD-binding PCMH-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016819; AAS53811.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_985987.1; -.

3D structure databases

ModBase

Q752Y3.

Organism-specific databases

AGD

AFR440C; -.

Ontologies

GO:0031966;	Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR007173; ALO.
IPR010031; FAD_lactone_oxidase.
IPR006094; Oxid_FAD_bind_N.
IPR006093; Oxy_OxRdtase_FAD_BS.
Graphical view of domain structure.

Pfam

PF04030; ALO; 1.
PF01565; FAD_binding_4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01678; FAD_lactone_ox; 1.

PROSITE

PS51387; FAD_PCMH; 1.
PS00862; OX2_COVAL_FAD; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q752Y3.

Genome annotation databases

4622264; -.

fig|33169.1.peg.3632; -.

Phylogenomic databases

HOGENOM

Q752Y3; -.

Other

ProtoNet

Q752Y3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Oxidoreductase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 532`	`532`	`D-arabinono-1,4-lactone oxidase.`	`PRO_0000128163`
`DOMAIN`	`25 199`	`175`	`FAD-binding PCMH-type.`
`MOD_RES`	`62 62`		`Tele-8alpha-FAD histidine (By similarity).`

Sequence information

Length: 532 AA [This is the length of the unprocessed precursor]

Molecular weight: 59965 Da [This is the MW of the unprocessed precursor]

CRC64: 8B975E346283331C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVLAGVEAS GIARNYVFKN WAGIYSARPR LYFQPRSEDE VVAIVRAARE QGRTIVTVGS 

        70         80         90        100        110        120 
GHSPSDMCAT DDWMVNLDRL NGVLELQEDE QGRYADVTVA AGIRVYELHR YLSARGYALQ 

       130        140        150        160        170        180 
NLGSISEQSV GGIISTGTHG SSPYHGLVSS QYVNLTLVNG RGELVFLDSE HEPEVFRAAM 

       190        200        210        220        230        240 
LSLGKLGIIV RATIRVVPAF NIHSTQEVIN FETLLDNWET IWTSSEFIRC WWYPYVRKCV 

       250        260        270        280        290        300 
LWRGVKTSEP AEKSRSSWWG TTLGRLVYES LLWLTVNVYP SLTPFVERFI FRQQYGKVET 

       310        320        330        340        350        360 
FGNGDEAVQT SIDGLNMDCL FSQFVDEWAC PLNNGPEVLR SLDHSIAQAA QNKEFFVHVP 

       370        380        390        400        410        420 
IEVRCSNTTL PHEYKCPEDR TVTAPGPVYG NLLRPYLDNT PSHLRYAPLS DVTNSQLTLY 

       430        440        450        460        470        480 
INATIYRPFG TNTPIHKWFT LFEDTLGAAG GKPHWAKNFL GSTATAAGPV KSSDEYQDYE 

       490        500        510        520        530 
MRGMATKIKE WYGDNLKQFQ KVRREQDPHN VFIANKDWAV KNGIIDIDEL DS

Q752Y3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools