NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

FUNCTION: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids (By similarity).
CATALYTIC ACTIVITY: Acyl-CoA + NADP⁺ = trans-2,3-dehydroacyl-CoA + NADPH.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016818; AAS52604.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_984780.1; -.

3D structure databases

ModBase

Q757U3.

Organism-specific databases

AGD

AEL081W; -.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
Pfam graphical view of domain structure.

BLOCKS

Q757U3.

Genome annotation databases

4620970; -.

fig|33169.1.peg.2425; -.

Phylogenomic databases

HOGENOM

Q757U3; -.

Other

ProtoNet

Q757U3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Fatty acid biosynthesis; Lipid synthesis; Mitochondrion; NADP; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 376`		`Probable trans-2-enoyl-CoA reductase, mitochondrial.`	`PRO_0000000896`

Sequence information

Length: 376 AA [This is the length of the unprocessed precursor]

Molecular weight: 41467 Da [This is the MW of the unprocessed precursor]

CRC64: DFF107B8D6215ABE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQALNTTKRL MSTKQFPLFK SLLYSSHDPA DCTQVLKVHS YTPKVGADES ILLRTLAFPI 

        70         80         90        100        110        120 
NPSDINQLQG VYPSVPEKTL DYSTEKPAAI AGNEGVFEVM SVPQGERRLA VGDWVIPLYS 

       130        140        150        160        170        180 
NTGTWTNYQT CRDAGTLVKV NGLDLYTAAT IAVNGCTAYQ LVNDYVQWDP SGNEWIVQNA 

       190        200        210        220        230        240 
GTSAVSKIVT QVAQARGVKT LSVIRDRENF AEVAKELEER YGATKVISET QNNDKDFSKD 

       250        260        270        280        290        300 
ELPVILGPNA RVRLALNSVG GKSSGAIARK LERDGTMLTY GGMSRQPVTV PTTLLIFNGL 

       310        320        330        340        350        360 
KSLGYWITEN TKRNPQSKID TISVLMRMYG DGQLQPPEAD IKKIEWDVQK MNDEQLLEAV 

       370 
KNGIQSNGKS VVVLKW

Q757U3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools