NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016816; AAS51163.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_983339.1; -.

3D structure databases

SMR

Q75CI4; 26-259.

ModBase

Q75CI4.

Organism-specific databases

AGD

ACL065C; -.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q75CI4.

Genome annotation databases

4619459; -.

fig|33169.1.peg.984; -.

Phylogenomic databases

HOGENOM

Q75CI4; -.

Other

ProtoNet

Q75CI4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion.`
`CHAIN`	`? 261`		`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial.`	`PRO_0000010347`
`DOMAIN`	`31 122`	`92`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`164 194`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`82 82`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`87 87`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`90 90`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`102 102`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`174 174`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`177 177`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`180 180`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`184 184`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`231 231`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`237 237`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`241 241`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`189 189`		`Ubiquinone; shared with DHSD (By similarity).`

Sequence information

Length: 261 AA [This is the length of the unprocessed precursor]

Molecular weight: 29436 Da [This is the MW of the unprocessed precursor]

CRC64: 7F11084887FC7F5A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVFRAGIGRI GLIRGLATQA AEVSATRYKS FKIYRWNPDT PAEKPRMQEY KVDLNKCGPM 

        70         80         90        100        110        120 
VLDALIKIKN EQDPTLTFRR SCREGICGSC AMNIGGRNTL ACLCKIDQAE NKDVKIYPLP 

       130        140        150        160        170        180 
HMYVVKDLVP DLTNFYKQYK SIQPYLQKAS KPADGREHLQ SIADRKKLDG LYECILCACC 

       190        200        210        220        230        240 
STACPSYWWN NEQYLGPAVL MQAYRWMVDS RDGAGAGRRE QLQNAMSVYR CHTIMNCTRT 

       250        260 
CPKGLNPGKA IAEIKKALAF A

Q75CI4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools