ID   LOX1_ORYSJ              Reviewed;         863 AA.
AC   Q76I22; Q7G786;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-NOV-2008, entry version 38.
DE   RecName: Full=Lipoxygenase 1;
DE            EC=1.13.11.12;
DE   AltName: Full=9-lipoxygenase;
DE   AltName: Full=r9-LOX1;
GN   OrderedLocusNames=Os03g0699700, LOC_Os03g49260;
GN   ORFNames=OSJNBb0017F17.10;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   MEDLINE=22996829; PubMed=14634153; DOI=10.1093/pcp/pcg142;
RA   Mizuno K., Iida T., Takano A., Yokoyama M., Fujimura T.;
RT   "A new 9-lipoxygenase cDNA from developing rice seeds.";
RL   Plant Cell Physiol. 44:1168-1175(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R.,
RA   Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L.,
RA   Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S., Johri S.,
RA   Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S.,
RA   Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J.,
RA   de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y.,
RA   Kim H.-I., Rambo T., Currie J., Collura K., Kernodle-Thompson S.,
RA   Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L.,
RA   Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C.,
RA   Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L.,
RA   Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H.,
RA   Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome
RT   3 and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
CC   -!- FUNCTION: Plant lipoxygenase may be involved in a number of
CC       diverse aspects of plant physiology including growth and
CC       development, pest resistance, and senescence or responses to
CC       wounding. This lipoxygenase introduces molecular oxygen
CC       exclusively into the C-9 position of linoleic and linolenic.
CC   -!- CATALYTIC ACTIVITY: Linoleate + O(2) = (9Z,11E)-(13S)-13-
CC       hydroperoxyoctadeca-9,11-dienoate.
CC   -!- COFACTOR: Binds 1 iron ion per subunit. Iron is tightly bound (By
CC       similarity).
CC   -!- PATHWAY: Lipid metabolism; oxylipin biosynthesis.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- DEVELOPMENTAL STAGE: Expressed in the embryo 1 day after
CC       inbibition, and at low levels in developing seeds between 3 and 20
CC       days after flowering.
CC   -!- SIMILARITY: Belongs to the lipoxygenase family.
CC   -!- SIMILARITY: Contains 1 lipoxygenase domain.
CC   -!- SIMILARITY: Contains 1 PLAT domain.
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DR   EMBL; AB099850; BAD02945.1; -; mRNA.
DR   EMBL; AC097368; AAO38440.1; -; Genomic_DNA.
DR   EMBL; AC093017; AAX95631.1; -; Genomic_DNA.
DR   RefSeq; NP_001050990.1; -.
DR   UniGene; Os.18598; -.
DR   HSSP; P08170; 2SBL.
DR   GeneID; 4333818; -.
DR   KEGG; osa:4333818; -.
DR   Gramene; Q76I22; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016165; F:lipoxygenase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0031408; P:oxylipin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000907; LipOase.
DR   InterPro; IPR013819; LipOase_C.
DR   InterPro; IPR001024; LipOase_LH2.
DR   InterPro; IPR001246; LipOase_pln.
DR   Gene3D; G3DSA:2.60.60.20; Lipase_LipOase; 1.
DR   PANTHER; PTHR11771; LipOase; 1.
DR   Pfam; PF00305; Lipoxygenase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PRINTS; PR00087; LIPOXYGENASE.
DR   PRINTS; PR00468; PLTLPOXGNASE.
DR   SMART; SM00308; LH2; 1.
DR   PROSITE; PS00711; LIPOXYGENASE_1; 1.
DR   PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR   PROSITE; PS51393; LIPOXYGENASE_3; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Dioxygenase; Fatty acid biosynthesis; Iron;
KW   Lipid synthesis; Metal-binding; Oxidoreductase; Oxylipin biosynthesis.
FT   CHAIN         1    863       Lipoxygenase 1.
FT                                /FTId=PRO_0000220707.
FT   DOMAIN       32    158       PLAT.
FT   DOMAIN      161    863       Lipoxygenase.
FT   METAL       518    518       Iron; catalytic (By similarity).
FT   METAL       523    523       Iron; catalytic (By similarity).
FT   METAL       709    709       Iron; catalytic (By similarity).
FT   METAL       713    713       Iron; catalytic (By similarity).
FT   METAL       863    863       Iron; via carboxylate; catalytic (By
FT                                similarity).
FT   CONFLICT    160    160       N -> I (in Ref. 1; BAD02945).
FT   CONFLICT    163    163       L -> P (in Ref. 1; BAD02945).
FT   CONFLICT    513    513       H -> R (in Ref. 1; BAD02945).
FT   CONFLICT    527    527       E -> K (in Ref. 1; BAD02945).
FT   CONFLICT    596    596       T -> A (in Ref. 1; BAD02945).
FT   CONFLICT    663    663       E -> A (in Ref. 1; BAD02945).
SQ   SEQUENCE   863 AA;  97499 MW;  AA8309F3DBCEC2F1 CRC64;
     MLGGLKDKLT GKNGNKIKGL AVLMSRKLLD PRDFTASLLD NVHEVFGNSI TCQLVSATVA
     DQNNEGRGIV GSEANLEQGL TDLPSVSQGE SKLTVRFNWE MDKHGVPGAI IIKNHHSTKF
     FLKTITLHDV PGCDTIVFVA NSWIYPVGKY HYNRIFFANN SYLPSQMPEA LRPYREDELR
     YLRGEDRQGP YQEHDRIYRY DVYNDLGEPD RDNPRPVLGG SQKHPYPRRG RTGRIPTKKD
     PNSESRLSLL EQIYVPSDER FAHLKMSDFA GYSIKAIVQG ILPAIRTYVD LTPGEFDSFE
     DILKLYRGGL KLPSIPALEE LRKSFPVQLI KDLLPVGGSY LLKFPKPDII KENEVAWRTD
     EEFAREILAG LNPMVIRRLT EFPPKSTLDP SKYGDQTSTI TPAHIEKNLE GLSVQQALDS
     NRLYILDHHD HFMPFLIDIN SLDGIFTYAT RTLLFLRDDD TLKPLAIELS LPHIEGNLTS
     AKSKVHTPAS SGIESWVWQL AKAYVAVNDS GWHQLISHWL NTHAVMEPFV IATNRQLSVT
     HPVYKLLQPH YRDTMTINAL ARQTLINGGG IFEQTVFPGK HALAMSSAVY KNWNFTEQGL
     PDDLIKRGIA IKDPSSPSKV KLLIKDYPYA TDGLAIWQAI EQWVTEYCAI YYPNDGVLQG
     DVELQAWWKE VREVGHGDLK DADWWPKMQS LPELTKACTT IIWIASALHA AVNFGQYPYA
     GYLPNRPTIS RRPMPEPGSK EYTELDENPE KFFIRTITSQ FQTILGVSLI EILSKHSADE
     IYLGQRDTPE WTSDPKALEA FKRFSRQLVE IESKVLNMNK DPLLKNRVGP ANFPYTLMFP
     NTSDNKGAAE GITARGIPNS ISI
//