NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(02)08713-5; PubMed=12044378 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
"Genome and virulence determinants of high virulence community-acquired MRSA.";
Lancet 359:1819-1827(2002).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000033; BAB95322.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_646274.1; -.

3D structure databases

ModBase

Q7A0U1.

Enzyme and pathway databases

BioCyc

SAUR196620:MW1457-MON; -.

Family and domain databases

InterPro

IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGRFAMs

TIGR00112; proC; 1.

BLOCKS

Q7A0U1.

Genome annotation databases

GeneID

1003569; -.

GenomeReviews

BA000033_GR; MW1457.

KEGG

sam:MW1457; -.

Phylogenomic databases

HOGENOM

Q7A0U1; -.

Genome annotation databases

CMR

Q7A0U1; MW1457.

Other

ProtoNet

Q7A0U1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 271`	`271`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187303`

Sequence information

Length: 271 AA [This is the length of the unprocessed precursor]

Molecular weight: 29826 Da [This is the MW of the unprocessed precursor]

CRC64: BBFB9C15896A9633 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKLVFYGAGN MAQAIFTGII NSSNLDANDI YLTNKSNEQA LKAFAEKLGV NYSYDDATLL 

        70         80         90        100        110        120 
KDADYVFLGT KPHDFDALAT RIKPHITKDN CFISIMAGIP IDYIKQQLEC QNPVARIMPN 

       130        140        150        160        170        180 
TNAQVGHSVT GISFSNNFDP KSKDEINDLV KAFGSVIEVS EDHLHQVTAI TGSGPAFLYH 

       190        200        210        220        230        240 
VFEQYVKAGT KLGLEKEQVE ESIRNLIIGT SKMIERSDLS MAQLRKNITS KGGTTQAGLD 

       250        260        270 
TLSQYDLVSI FEDCLNAAVD RSIELSNVED Q

Q7A0U1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools