NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(02)08713-5; PubMed=12044378 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
"Genome and virulence determinants of high virulence community-acquired MRSA.";
Lancet 359:1819-1827(2002).

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000033; BAB94007.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_644957.1; -.

3D structure databases

HSSP

P20000; 1AG8. [HSSP ENTRY / PDB]

ModBase

Q7A1Y7.

Enzyme and pathway databases

BioCyc

SAUR196620:MW0142-MON; -.

Ontologies

GO:0004029;	Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

Q7A1Y7.

Genome annotation databases

GeneID

1004895; -.

GenomeReviews

BA000033_GR; MW0142.

KEGG

sam:MW0142; -.

Phylogenomic databases

HOGENOM

Q7A1Y7; -.

Genome annotation databases

CMR

Q7A1Y7; MW0142.

Other

ProtoNet

Q7A1Y7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 495`	`495`	`Putative aldehyde dehydrogenase aldA.`	`PRO_0000056460`
`NP_BIND`	`212 218`	`7`	`NAD (By similarity).`
`ACT_SITE`	`256 256`		`By similarity.`
`ACT_SITE`	`290 290`		`By similarity.`

Sequence information

Length: 495 AA [This is the length of the unprocessed precursor]

Molecular weight: 53660 Da [This is the MW of the unprocessed precursor]

CRC64: 36B448F85BFECD02 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAVNVRDYIA ENYGLFINGE FVKGSSDETI EVTNPATGET LSHITRAKDK DVDHAVKVAQ 

        70         80         90        100        110        120 
EAFESWSLTS KSERAQMLRD IGDKLMAQKD KIAMIETLNN GKPIRETTAI DIPFAARHFH 

       130        140        150        160        170        180 
YFASVIETEE GTVNDIDKDT MSIVRHEPIG VVGAVVAWNF PMLLAAWKIA PAIAAGNTIV 

       190        200        210        220        230        240 
IQPSSSTPLS LLEVAKIFQE VLPKGVVNIL TGKGSESGNA IFNHDGVDKL SFTGSTDVGY 

       250        260        270        280        290        300 
QVAEAAAKHL VPATLELGGK SANIILDDAN LDLAVEGIQL GILFNQGEVC SAGSRLLVHE 

       310        320        330        340        350        360 
KIYDQLVPRL QEAFSNIKVG DPQDEATQMG SQTGKDQLDK IQSYIDAAKE SDAQILAGGH 

       370        380        390        400        410        420 
RLTENGLDKG FFFEPTLIAV PDNHHKLAQE EIFGPVLTVI KVKDDQEAID IANDSEYGLA 

       430        440        450        460        470        480 
GGVFSQNITR ALNIAKAVRT GRIWINTYNQ VPEGAPFGGY KKSGIGRETY KGALSNYQQV 

       490 
KNIYIDTSNA LKGLY

Q7A1Y7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools