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UniProtKB/Swiss-Prot entry Q7MHL0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name E4PD_VIBVY
Primary accession number Q7MHL0
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name D-erythrose-4-phosphate dehydrogenase
Synonyms E4PDH
EC 1.2.1.72
Gene name
Name: epd
OrderedLocusNames: VV2859
From
Vibrio vulnificus (strain YJ016) [TaxID: 196600] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.1295503; PubMed=14656965 [NCBI, ExPASy, EBI, Israel, Japan]
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.;
"Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
Genome Res. 13:2577-2587(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000037; BAC95623.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_935652.1; -.
3D structure databases
HSSP P00362; 1GD1. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q7MHL0.
Enzyme and pathway databases
BioCyc VVUL196600:VV2859-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0048001; Molecular function: erythrose-4-phosphate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008615; Biological process: pyridoxine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01640; -; 1.
PBIL [Tree]
InterPro IPR006422; E4P_DHase_bac.
IPR000173; GlycerAld_3-P_DHase.
Graphical view of domain structure.
PANTHER PTHR10836; GAP_DH; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
PRINTS PR00078; G3PDHDRGNASE.
TIGRFAMs TIGR01532; E4PD_g-proteo; 1.
PROSITE PS00071; GAPDH; FALSE_NEG.
BLOCKS Q7MHL0.
Genome annotation databases
GeneID 2625677; -.
GenomeReviews BA000037_GR; VV2859.
KEGG vvy:VV2859; -.
NMPDR fig|196600.1.peg.2927; -.
Phylogenomic databases
HOGENOM Q7MHL0; -.
Genome annotation databases
CMR Q7MHL0; VV2859.
Other
ProtoNet Q7MHL0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NAD; Oxidoreductase; Pyridoxine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   346  346     D-erythrose-4-phosphate dehydrogenase. PRO_0000293177
NP_BIND   11    12  2     NAD (By similarity). 
REGION   163   165  3     Substrate binding (Potential). 
REGION   222   223  2     Substrate binding (Potential). 
ACT_SITE   164   164        Nucleophile (By similarity). 
BINDING   209   209        Substrate (Potential). 
BINDING   245   245        Substrate (Potential). 
BINDING   327   327        NAD (By similarity). 
SITE   191   191  1     Activates thiol group during catalysis (By similarity). 
Sequence information
Length: 346 AA [This is the length of the unprocessed precursor] Molecular weight: 38189 Da [This is the MW of the unprocessed precursor] CRC64: 645B7FFE1F82C837 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLKVAINGFG RIGRNVLRAV YESGKHQQIK VVAVNELAQP EAMAHLLQYD TSHGRFGKRI 

        70         80         90        100        110        120 
SHDQEHLYVH HDACPQGKGE FDSIRILHLS EINLLPWRDL EVDLVLDCTG VFGCQADGLE 

       130        140        150        160        170        180 
HIKAGAKKVL FSHPGASDLD NTIIYGVNHE TLKAEHNVVS NGSCTTNCIV PIIKVLDEAF 

       190        200        210        220        230        240 
GIESGTITTI HSSMNDQQVI DAYHSDLRRT RAASQSIIPV DTKLHKGIER IFPKFSNKFE 

       250        260        270        280        290        300 
AISVRVPTVN VTAMDLSVTI NTNVKVNDVN QTIVNASQCT LRGIVDYTEA PLVSIDFNHD 

       310        320        330        340 
PHSAIVDGSQ TRVSNGHLVK MLVWCDNEWG FANRMLDTAL AMQAAK
Q7MHL0 in FASTA format

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