ID   ASTD_PHOLL              Reviewed;         491 AA.
AC   Q7N2G9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-NOV-2008, entry version 36.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=plu3108;
OS   Photorhabdus luminescens subsp. laumondii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Photorhabdus.
OX   NCBI_TaxID=141679;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TT01;
RX   MEDLINE=22957627; PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S.,
RA   Medigue C., Lanois A., Powell K., Siguier P., Vincent R., Wingate V.,
RA   Zouine M., Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; BX571869; CAE15482.1; -; Genomic_DNA.
DR   RefSeq; NP_930340.1; -.
DR   GeneID; 2803119; -.
DR   GenomeReviews; BX470251_GR; plu3108.
DR   KEGG; plu:plu3108; -.
DR   NMPDR; fig|243265.1.peg.2964; -.
DR   PhotoList; plu3108; -.
DR   HOGENOM; Q7N2G9; -.
DR   BioCyc; PLUM243265:PLU3108-MON; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:InterPro.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    491       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000262410.
FT   NP_BIND     223    228       NAD (By similarity).
FT   ACT_SITE    246    246       By similarity.
FT   ACT_SITE    280    280       By similarity.
SQ   SEQUENCE   491 AA;  53316 MW;  096BDDC09308DFD5 CRC64;
     MNYKAHYIGG RWIEGQGESI TKFSPIDQQV LWQANSADAS QVRAACHAAR EAFYAWSHLP
     ASERIKVIQT FAALLNEEKE TLARVISQET SKPLWETRTE IQSMIGKAAI SIEAWEQRTG
     ESETIMPDGR ALLRHRPHGV MAVFGPYNFP GHLPNGHIIP ALIAGNTLVF KPSELTPMTA
     EETVKLWEKA GLPAGVLNLV QGARSTGTAL LEDKQIDGVL FTGSANTGFH FHRMLGGQPE
     KMLALEMGGN NALIVDAYDD IDAAVYTIVQ SAFISAGQRC TCARRLLVKN GAHGDAVIKR
     LVEVTERIVP SHWDAQPQPF IGGVISLQAV QNLLEAQDRL QKLGGISLVS LEQCQPQSTL
     LTPGIIDVSQ VADVPDEEYF GPLLMLMRYD TFDEALAIAN NTRFGLATGL ISPDAALFQR
     LSEDARAGIV NWNKPLTGAS SKAPFGGIGA SGNYRPSAYY AADYCAWPMA SLVADELTLP
     ETLAPGLHFP D
//