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UniProtKB/Swiss-Prot entry Q7N6K4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_PHOLL
Primary accession number Q7N6K4
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 32)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: plu1546
From
Photorhabdus luminescens subsp. laumondii [TaxID: 141679] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Photorhabdus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TT01;
DOI=10.1038/nbt886; PubMed=14528314 [NCBI, ExPASy, EBI, Israel, Japan]
Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F.;
"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.";
Nat. Biotechnol. 21:1307-1313(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571864; CAE13839.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_928837.1; -.
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase Q7N6K4.
Enzyme and pathway databases
BioCyc PLUM243265:PLU1546-MON; -.
Organism-specific databases
PhotoList plu1546; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0006108; Biological process: malate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
ProtoNet Q7N6K4.
Genome annotation databases
GeneID 2801541; -.
GenomeReviews BX470251_GR; plu1546.
KEGG plu:plu1546; -.
NMPDR fig|243265.1.peg.1461; -.
Phylogenomic databases
HOGENOM Q7N6K4; -.
Genome annotation databases
CMR Q7N6K4; plu1546.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   565  565     NAD-dependent malic enzyme. PRO_0000160220
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   418   418        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 565 AA [This is the length of the unprocessed precursor] Molecular weight: 63000 Da [This is the MW of the unprocessed precursor] CRC64: F15FE165CCAC9CC7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MELEHESKRP LYIPYSGPIL LEFPLLNKGS AFTEEERRNF NLHGLLPEAV ETIEEQAERA 

        70         80         90        100        110        120 
YRQYLDFKND ADKHIYLRNI QDTNETLFYR LLDAHLNEMM PIIYTPTVGE ACEHFSDIYR 

       130        140        150        160        170        180 
RARGLFISHP NKAHIDDMLQ NATKQNVKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
SCGGISPAYT LPVVLDVGTN NPQRLNDPLY MGWRHPRITG KEYDEFVDEF IQAVKRRWPN 

       250        260        270        280        290        300 
VLLQFEDFAQ KNAMPLLNRY RHEICCFNDD IQGTAAVTLG SLIAASRAAG RQLKDQTVTF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIVAQMKS EGLSDEQARA RIFMVDRFGL LTDKLPNLLD FQNKLVQKSS 

       370        380        390        400        410        420 
SLAKWDVNND SISLLDVVRN AKPTVLIGVS GQAGLFTEEI IREMHKHCER PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEARPEDI INWTDGAALV ATGSPFNPVK YKDQEYPIAQ CNNAYIFPGI GLGVIASGAK 

       490        500        510        520        530        540 
LVTDGMLMAA SRTLANCSPL AQEGQGPLLP LIDDIQEVSR KIAKQVAKEA QIQGVATVTS 

       550        560 
DGALDEAIER NFWKPEYRVY KRTSF
Q7N6K4 in FASTA format

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