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UniProtKB/Swiss-Prot entry Q7Q547


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HOT_ANOGA
Primary accession number Q7Q547
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on January 9, 2007 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 30)
Name and origin of the protein
Protein name Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial [Precursor]
Synonyms HOT
EC 1.1.99.24
Gene name
ORFNames: AGAP006646
From
Anopheles gambiae (African malaria mosquito) [TaxID: 7165] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PEST;
DOI=10.1126/science.1076181; PubMed=12364791 [NCBI, ExPASy, EBI, Israel, Japan]
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
"The genome sequence of the malaria mosquito Anopheles gambiae.";
Science 298:129-149(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAAB01008960; EAA10782.3; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_316676.3; -.
3D structure databases
ModBase Q7Q547.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from sequence or structural similarity from UniProtKB).
GO:0047988; Molecular function: hydroxyacid-oxoacid transhydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0015993; Biological process: molecular hydrogen transport (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001670; Fe_AlcDHase.
Graphical view of domain structure.
Pfam PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.
PROSITE PS00913; ADH_IRON_1; FALSE_NEG.
PS00060; ADH_IRON_2; FALSE_NEG.
BLOCKS Q7Q547.
Genome annotation databases
GeneID 1277230; -.
KEGG aga:AgaP_AGAP006646; -.
VectorBase AGAP006646; Anopheles gambiae.
Other
ProtoNet Q7Q547.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   464        Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial. PRO_0000323004
Sequence information
Length: 464 AA [This is the length of the unprocessed precursor] Molecular weight: 49722 Da [This is the MW of the unprocessed precursor] CRC64: 05C5103EC6A471D4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWNRGRIVSL MRTVSSGSCS CPAHSRPVAI SQQTSCSAEK DTAFEMSSST IRYGPGVTRE 

        70         80         90        100        110        120 
LGHDLQNLGA KSVCVVSDRN VLQLPSVKVG LDAIVRAGIE PVLFDAVRVE PTNESLQTAI 

       130        140        150        160        170        180 
DFARSHRFDA FVAIGGGSAI DTCKVANLYS ADREAEFLDY VNVPIGRAKE VTVPLKPLIA 

       190        200        210        220        230        240 
VPTTAGTGSE TTGVAIFDHK PLHAKTGISS KALRPILGLV DPLHTLSQPE KVAAYCGFDV 

       250        260        270        280        290        300 
FCHALESFTA IPYTERGPAP ANPKLRPPYQ GSNPISDVWA RFALQTISRH FRRAVYAPDD 

       310        320        330        340        350        360 
LEARSQMHLA STMAGVGFGN AGVHLCHGLS YPIAGLVKQF IPDGYTGAHP IIPHGLSVVM 

       370        380        390        400        410        420 
TAPSVFRFTG ASCPDRHLEA AGILGADVAK SHRNDAGAIL ADTVRRYMHD LKIENGLSAL 

       430        440        450        460 
GFNYSDIPAL VKGTLPQERI TKLAPRAQSE EDLAGLFEQS LTVY 

Q7Q547 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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