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UniProtKB/Swiss-Prot entry Q7QC84


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_ANOGA
Primary accession number Q7QC84
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on December 7, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 40)
Name and origin of the protein
Protein name Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Gene name
ORFNames: AGAP002499
From
Anopheles gambiae (African malaria mosquito) [TaxID: 7165] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PEST;
DOI=10.1126/science.1076181; PubMed=12364791 [NCBI, ExPASy, EBI, Israel, Japan]
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
"The genome sequence of the malaria mosquito Anopheles gambiae.";
Science 298:129-149(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAAB01008859; EAA07972.4; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_312441.4; -.
3D structure databases
ModBase Q7QC84.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity (inferred from electronic annotation from EC).
GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006573; Biological process: valine metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
ProtoNet Q7QC84.
Genome annotation databases
Ensembl AGAP002499; Anopheles gambiae. [Contig view]
GeneID 1273463; -.
KEGG aga:AgaP_AGAP002499; -.
VectorBase AGAP002499; Anopheles gambiae.
Phylogenomic databases
HOGENOM Q7QC84; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   521        Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000043372
NP_BIND   196   200  5     NAD (Potential). 
NP_BIND   248   253  6     NAD (Potential). 
ACT_SITE   304   304        Nucleophile (By similarity). 
BINDING   404   404        NAD (Potential). 
Sequence information
Length: 521 AA [This is the length of the unprocessed precursor] Molecular weight: 56714 Da [This is the MW of the unprocessed precursor] CRC64: C32B9871C0464F42 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALLRLVATE CRNVLQRGYS TASVPTTKMF IDGKFVESKT NDWIDLHDPA TNEVVTRVPK 

        70         80         90        100        110        120 
CTQDEMQTAV ESSKKAYKTW RQSSILSRQQ VMLKLQHIIR NNMSELAKNI TKEQGKTLID 

       130        140        150        160        170        180 
AEGDVLRGLQ VVEHCCSITS LQMGETVPNI AKDMDTYSYH LPLGVTAGIA PFNFPAMIPL 

       190        200        210        220        230        240 
WMFPVAITCG NTSIIKPSER VPGATMLLME MLNEAGCPPG VVNVIHGAHD AVNFVCDNPD 

       250        260        270        280        290        300 
IRAVSFVGSD QAGKYIYERA GRNGKRVQCN MGAKNHGVIM ADANKENTLN QLAGAAFGAA 

       310        320        330        340        350        360 
GQRCMALSTA VFVGEARNWI PDLVERARKL KVNAGHLPGT DLGPVISPQS KQRINELVES 

       370        380        390        400        410        420 
GAKEGAKIVL DGRNIKVEGF EKGNFVGPTI ISDVTPNMKC YTEEIFGPVL VCLSVDTIDE 

       430        440        450        460        470        480 
AIELINNNPY GNGTAIFTTN GATARKFVND IDVGQVGVNV PIPVPLPMFS FTGSRGSFLG 

       490        500        510        520 
DCHFYGKQGI KFYTQTKTVT QLWREGDVSH TKAAVAMPTM K 

Q7QC84 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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