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UniProtKB/Swiss-Prot entry Q7RX99

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG1_NEUCR
Primary accession number Q7RX99
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name Serine/threonine-protein kinase atg-1
Synonyms EC 2.7.11.1
Autophagy-related protein 1
Gene name
Name: atg-1
ORFNames: NCU00188
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AABX02000001; EAA27175.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_956411.1; -.
3D structure databases
HSSP P49137; 1NY3. [HSSP ENTRY / PDB]
ModBase Q7RX99.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004674; Molecular function: protein serine/threonine kinase activity (inferred from electronic annotation from InterPro).
GO:0006914; Biological process: autophagy (inferred from electronic annotation from UniProtKB-KW).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
GO:0015031; Biological process: protein transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q7RX99.
Genome annotation databases
GeneID 3872551; -.
KEGG ncr:NCU00188; -.
NMPDR fig|5141.1.peg.207; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   932  932     Serine/threonine-protein kinase atg-1. PRO_0000085649
DOMAIN   24   329  306     Protein kinase. 
NP_BIND   30    38  9     ATP (By similarity). 
ACT_SITE   167   167        Proton acceptor (By similarity). 
BINDING   53    53        ATP (By similarity). 
Sequence information
Length: 932 AA [This is the length of the unprocessed precursor] Molecular weight: 102663 Da [This is the MW of the unprocessed precursor] CRC64: 399DBDEABF6500EF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSDRTSASSS SRRTKQNYDA IGSFVIDQEI GKGSFAKVYL GRHKVTGALV AVKSVELARL 

        70         80         90        100        110        120 
NKKLKENLYG EIQILKTLRH PHIVALHDCV ESSTHINLIM EYCELGDLSL FIKKRDKLIT 

       130        140        150        160        170        180 
NPYTHDLARK YPVYPNAGLN EVVTRHFLKQ LASALQFLRA GDFVHRDVKP QNLLLLPSPH 

       190        200        210        220        230        240 
MMANNKTAKH IMSGSYDSFT PAAGLASAPM LKLADFGFAR VLPSTSLAET LCGSPLYMAP 

       250        260        270        280        290        300 
EILRYEKYDA KADLWSVGTV LYEMVTGRPP FKASNHVELL RKIESSGDVI KFTRESVVSQ 

       310        320        330        340        350        360 
EMKGLIRALL KKNPVERISF EDLFNHPVVT EPIPGLVEDD IPKPPRRRSL KEERPVSRAE 

       370        380        390        400        410        420 
DSLVPSRKQS LRKDLADREG APQTAGPSSP KPRRSSPLAT PNEPVEISKP NYFQIPPRED 

       430        440        450        460        470        480 
RLSYSPRKEA ADGLGIKRPQ VQPSTSAPTR PSSYVDRRHR SSNASLRAPV REANPPPNDV 

       490        500        510        520        530        540 
TRTKPRGMGT KPMTEEERAA QDIAFERDYV LVDKKHLEVN ALADQISMYP QQPQSPKSAQ 

       550        560        570        580        590        600 
IVRRATQQGS PTSTSGAVPS PPSRALQLAQ GHSRQGSYDK ALGTSPSKAT SVISKAIQDA 

       610        620        630        640        650        660 
SLRLFGFKYA PHLLSKGPSP VPMYNPFPTY PAPNTPTGLI SDGKQGTPVD EDSRVAQCIE 

       670        680        690        700        710        720 
DHATRSDVVY GFAEVKYKQL VPLAPSMDHG LGGAPIEKSA EEDGLTAEAI VSLSEEALVL 

       730        740        750        760        770        780 
YVKALTLLAK SMDIASLWWS RKNKVESTNS ITSAARDSAN SEALALRING AVQWIRSRFN 

       790        800        810        820        830        840 
EVLEKAEIVR LKLAEAQKRL PEDHPSHPNN HANDSTALNS LSTVGVFLSE GISAERLMYD 

       850        860        870        880        890        900 
RAIEMSRAAA INEIANEDLP GCEISYITAI RMLEAVLDQD DDHLPKRKVS GASKEEKTGA 

       910        920        930 
NELSDEMNNE DKQVVQNGEP TSVLVQNKAS LY
Q7RX99 in FASTA format

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