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UniProtKB/Swiss-Prot entry Q7SY23

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL4A1_DANRE
Primary accession number Q7SY23
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [Precursor]
Synonyms P5C dehydrogenase
EC 1.5.1.12
Aldehyde dehydrogenase family 4 member A1
Gene name
Name: aldh4a1
ORFNames: zgc:63592
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC055155; AAH55155.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_957452.1; -.
UniGene Dr.84922
3D structure databases
ModBase Q7SY23.
Organism-specific databases
ZFIN ZDB-GENE-040426-1179; zgc:63592.
Gene expression databases
ArrayExpress Q7SY23; -.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005931; d-1-pyrroline-5-COlate_DHase-1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01236; D1pyr5carbox1; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q7SY23.
Genome annotation databases
Ensembl ENSDARG00000038207; Danio rerio. [Contig view]
GeneID 394133; -.
KEGG dre:394133; -.
Phylogenomic databases
HOGENOM Q7SY23; -.
HOVERGEN Q7SY23; -.
Other
ProtoNet Q7SY23.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Proline metabolism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    17  17     Mitochondrion (By similarity). 
CHAIN   18   556  539     Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial. PRO_0000007175
NP_BIND   289   294  6     NAD (By similarity). 
ACT_SITE   307   307        By similarity. 
ACT_SITE   341   341        By similarity. 
Sequence information
Length: 556 AA [This is the length of the unprocessed precursor] Molecular weight: 61587 Da [This is the MW of the unprocessed precursor] CRC64: E7973E9787CEA358 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRARSAVSQ SWKGFKTFSC VAVEVKNEPV LEFKEGSKER AELEEALRNL KGKTEEIPCV 

        70         80         90        100        110        120 
IGNEEVWTKD IRFQLSPFNH SHQVAKFCYA DKDLLNKAIE ASVAARREWD LKPVSDRAQI 

       130        140        150        160        170        180 
FFKAADIISG PKRAEVLAKT MIGQGKTVVQ AEIDAAPELI DFFRFNAKHA IELEDQQPLD 

       190        200        210        220        230        240 
SDGSTNTMLY RGLEGFVAAV APFNFTAIGG NLAGTPALMG NVVLWKPSDT AMSASYAVYK 

       250        260        270        280        290        300 
ILRESGLPPN IIQFVPADGP VFGDTVTSSE HLAGINFTGS VPTFKRLWKQ VAQNLDIYKN 

       310        320        330        340        350        360 
FPRVAGECGG KNFHFVHKSA DVRSVVTGTI RSAFEYGGQK CSACSRMYVP DSLWPQIRQG 

       370        380        390        400        410        420 
LLDVYKQIKV GDPVEDFSTF FSAVIDDKSF SRIKGWLEHA RSSPHLKIIA GGNCDDKKGY 

       430        440        450        460        470        480 
FVEPTIIETT DPQEKIMNEE IFGPVLTVYV YPENDYKKVL HLIDNTSPYA LTGAIFPQDK 

       490        500        510        520        530        540 
SVIEEAGKAL RNAAGNYYIN DKSTGSIVAQ QPFGGARASG TNDKPGGPHY VLRWTSPQVV 

       550 
KQTHVPLTEW KYPYMS
Q7SY23 in FASTA format

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