[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=AB; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-tryptophan + O₂ = N-formyl-L-kynurenine.
COFACTOR: Binds 2 heme groups per tetramer. The hemes are protoheme IV (By similarity).
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2 .
SIMILARITY: Belongs to the tryptophan 2,3-dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC055123; AAH55123.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_956150.1; -.

UniGene

Dr.80748

3D structure databases

ModBase

Q7SY53.

Organism-specific databases

ZFIN

ZDB-GENE-030131-6014; zgc:63488.

Family and domain databases

InterPro

IPR004981; Trp_2_3_dOase.
Graphical view of domain structure.

PANTHER

PTHR10138; Trp_2_3_dOase; 1.

Pfam

PF03301; Trp_dioxygenase; 1.
Pfam graphical view of domain structure.

BLOCKS

Q7SY53.

Genome annotation databases

Ensembl

ENSDARG00000023176; Danio rerio. [Contig view]

GeneID

334082; -.

KEGG

dre:334082; -.

Phylogenomic databases

HOGENOM

Q7SY53; -.

HOVERGEN

Q7SY53; -.

Other

ProtoNet

Q7SY53.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Heme; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 407`	`407`		`Tryptophan 2,3-dioxygenase.`	`PRO_0000247475`

Sequence information

Length: 407 AA [This is the length of the unprocessed precursor]

Molecular weight: 47422 Da [This is the MW of the unprocessed precursor]

CRC64: 8EA9740C0D4F3912 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGCPFLGGT LQLLSSNPRQ AEEEDGSQGG VNKAAKGGII YGDYLQLDKV LNAQVLQSEQ 

        70         80         90        100        110        120 
KGNKIHDEHL FIVTHQAYEL WFKQILWELD SVRDLFIKKH VRDERNMLKV VSRIHRITMI 

       130        140        150        160        170        180 
FKLLVDQFAV LETMTALDFF DFREYLSPAS GFQSLQFRLL EQKIGVADHL RVPYNRRHYR 

       190        200        210        220        230        240 
DNFHGEESET LLSSEQEPTL LQLVEQWLER TPGLEKDGFN FWGKLQANIE EGLKREKHQV 

       250        260        270        280        290        300 
EKMEDTEVKQ ELLEDLNKQM ETFTALFDSK RHEHLLSKGE RRLSYKALQG ALMINFYREE 

       310        320        330        340        350        360 
PRFQVPFQLL TALMEIDTLM TKWRYNHVCM VHRMIGSKAG TGGSSGYHYL RSTVSDRYKV 

       370        380        390        400 
FVDLFNLATF LVPRSWVPKL NPNIHKFPYT AECYDSSYNS CSSEDSD

Q7SY53 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools