ID   ACSF_PROMP              Reviewed;         390 AA.
AC   Q7V1M1;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-NOV-2008, entry version 38.
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
DE            EC=1.14.13.81;
GN   Name=acsF; OrderedLocusNames=PMM0844;
OS   Prochlorococcus marinus subsp. pastoris (strain CCMP1378 / MED4).
OC   Bacteria; Cyanobacteria; Prochlorales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22825698; PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P.,
RA   Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R.,
RA   Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M.,
RA   Shaw S.L., Steglich C., Sullivan M.B., Ting C.S., Tolonen A.,
RA   Webb E.A., Zinser E.R., Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic
RT   niche differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in
CC       chlorophyll biosynthesis. Mediates the cyclase reaction, which
CC       results in the formation of divinylprotochlorophyllide (Pchlide)
CC       characteristic of all chlorophylls from magnesium-protoporphyrin
CC       IX 13-monomethyl ester (MgPMME) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Magnesium-protoporphyrin IX 13-monomethyl
CC       ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX
CC       13-monomethyl ester + NADP(+) + H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-hydroxy-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-
CC       protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-oxo-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide +
CC       NADP(+) + 2 H(2)O.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis (light-
CC       independent).
CC   -!- SIMILARITY: Belongs to the acsF family.
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DR   EMBL; BX548174; CAE19303.1; -; Genomic_DNA.
DR   RefSeq; NP_892962.1; -.
DR   GeneID; 1727176; -.
DR   GenomeReviews; BX548174_GR; PMM0844.
DR   KEGG; pmm:PMM0844; -.
DR   NMPDR; fig|59919.1.peg.841; -.
DR   HOGENOM; Q7V1M1; -.
DR   BioCyc; PMAR167540:PMM0844-MON; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl este...; IEA:HAMAP.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:HAMAP.
DR   HAMAP; MF_01840; -; 1.
DR   InterPro; IPR008434; AcsF.
DR   InterPro; IPR003251; Rubrerythrin.
DR   Pfam; PF02915; Rubrerythrin; 1.
DR   TIGRFAMs; TIGR02029; AcsF; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Complete proteome; Iron; Metal-binding;
KW   NADP; Oxidoreductase; Photosynthesis.
FT   CHAIN         1    390       Magnesium-protoporphyrin IX monomethyl
FT                                ester [oxidative] cyclase.
FT                                /FTId=PRO_0000217532.
SQ   SEQUENCE   390 AA;  45980 MW;  A55456142B4B34BF CRC64;
     MAQQTIESNN KKSVNRGKDI AKDTILTPNF YTTDFEAMEK MDLSINEDEL EAICEEFRKD
     YNRHHFVRNK EFEGAADKID AETRELFVDF LEGSCTSEFS GFLLYKELSK RIKDKNPLLA
     ECFAHMARDE ARHAGFLNKS MNDFGLQLDL GFLTANKDYT YFAPRAIFYA TYISEKIGYW
     RYIAIYRHLE KNPSGKIFPL FNFFENWCQD ENRHGDFFDA LMKAQPRTVK SLSQKIEIFG
     YTLKHPIFDY YHRFRYFLNN HPIVSKLWSR FFLLAVFATM YIRDLGTKRN FYGALGLNAR
     EYDQFVINKT NETSAKVFPV VLNVYDKSFY KRLDRIVENG TRLSEIDKKE NPNVIKVLSK
     LPIFISNGYQ LIRLYLLKPL ESDDFQPSIR
//