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UniProtKB/Swiss-Prot entry Q7VVW3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOLD2_BORPE
Primary accession number Q7VVW3
Secondary accession numbers None
Integrated into Swiss-Prot on December 12, 2006
Sequence was last modified on December 12, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 29)
Name and origin of the protein
Protein name Bifunctional protein folD 2
Synonyms None
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Gene name
Name: folD2
OrderedLocusNames: BP2522
From
Bordetella pertussis [TaxID: 520] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX640418; CAE42794.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P11586; 1A4I. [HSSP ENTRY / PDB]
ModBase Q7VVW3.
Enzyme and pathway databases
BioCyc BPER257313:BP2522-MON; -.
Ontologies
GO
GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01576; -; 1.
PBIL [Tree]
InterPro IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Pfam PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00766; THF_DHG_CYH_1; FALSE_NEG.
PS00767; THF_DHG_CYH_2; 1.
BLOCKS Q7VVW3.
Genome annotation databases
GenomeReviews BX470248_GR; BP2522.
KEGG bpe:BP2522; -.
NMPDR fig|257313.1.peg.2223; -.
Phylogenomic databases
HOGENOM Q7VVW3; -.
Genome annotation databases
CMR Q7VVW3; BP2522.
Other
ProtoNet Q7VVW3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   283  283     Bifunctional protein folD 2. PRO_0000268288
Sequence information
Length: 283 AA [This is the length of the unprocessed precursor] Molecular weight: 29529 Da [This is the MW of the unprocessed precursor] CRC64: 0AB9732A92FD52AD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKAKVIDGSR ASARIREQLK ERVACLRARN IRPGLAVLLV GEDPASQVYV RNKVAACEQV 

        70         80         90        100        110        120 
GIHSVTERYP SAWTENQLLD RIASLHGDPA INGILVQLPL PPHMSAHRVI EAISPLKDVD 

       130        140        150        160        170        180 
GFHISNAGLL MTGKPQFQPC TPYGVMKLLE SEGVSLRGAE AVIVGASNIV GKPMAMLLLA 

       190        200        210        220        230        240 
AGATVTICNS KTRDLAGQAR RADVLIVAAG RAGIVDGSMI KPGAVVIDVG INRSPDGRLC 

       250        260        270        280 
GDVDYGSAAK VAGAITPVPG GVGPMTIAML LANTVEAAER SAI 

Q7VVW3 in FASTA format

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