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UniProtKB/Swiss-Prot entry Q7W2Y4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BORPA
Primary accession number Q7W2Y4
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BPP4267
From
Bordetella parapertussis [TaxID: 519] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX640436; CAE39546.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_886396.1; -.
3D structure databases
ModBase Q7W2Y4.
Enzyme and pathway databases
BioCyc BPAR257311:BPP4267-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002035; VWF_A.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR00453; VWFADOMAIN.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q7W2Y4.
Genome annotation databases
GeneID 1667362; -.
GenomeReviews BX470249_GR; BPP4267.
KEGG bpa:BPP4267; -.
Phylogenomic databases
HOGENOM Q7W2Y4; -.
Genome annotation databases
CMR Q7W2Y4; BPP4267.
Other
ProtoNet Q7W2Y4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   440  440     Histidinol dehydrogenase. PRO_0000135737
ACT_SITE   336   336        Proton acceptor (By similarity). 
ACT_SITE   337   337        Proton acceptor (By similarity). 
METAL   268   268        Zinc (By similarity). 
METAL   271   271        Zinc (By similarity). 
METAL   370   370        Zinc (By similarity). 
METAL   429   429        Zinc (By similarity). 
BINDING   139   139        NAD (By similarity). 
BINDING   200   200        NAD (By similarity). 
BINDING   223   223        NAD (By similarity). 
BINDING   246   246        Substrate (By similarity). 
BINDING   268   268        Substrate (By similarity). 
BINDING   271   271        Substrate (By similarity). 
BINDING   337   337        Substrate (By similarity). 
BINDING   370   370        Substrate (By similarity). 
BINDING   424   424        Substrate (By similarity). 
BINDING   429   429        Substrate (By similarity). 
Sequence information
Length: 440 AA [This is the length of the unprocessed precursor] Molecular weight: 46882 Da [This is the MW of the unprocessed precursor] CRC64: D8FC76AF462F129A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQYHDAMALI NRLDSRDPGF KTALSQLLAF EAEQDESIDQ AAAGILADVR RRGDAALLEY 

        70         80         90        100        110        120 
TQRFDRLAVD DATALEIPQA DWHAALDSLP AAQRQALEAA AARVRAYHER QRGETWTYTE 

       130        140        150        160        170        180 
ADGTMLGQQI TALDRVGLYV PGGKAAYPSS VLMNAIPAKV AGVPELIMVT PTPDGVRNPI 

       190        200        210        220        230        240 
VLAAAAIAGV DRAFAIGGAQ AVGALAYGTA TVPAVDKIVG PGNAYVAAAK RRVFGTVGID 

       250        260        270        280        290        300 
MIAGPSEILV ICDGKTPADW IAMDLFSQAE HDELAQSILL CPDAAFLAEV EAAIERLLPG 

       310        320        330        340        350        360 
MPRADILRVS LANRGALILV RDLEEACAIA NDIAPEHLEI STEQPQRWTA LIRHAGAIFM 

       370        380        390        400        410        420 
GRYSSEALGD YCAGPNHVLP TSRTARFSSP LGVYDFQKRS SLIQVSREGA QTLGRIAAEL 

       430        440 
ALGEGLQAHA ASAQYRLDQP
Q7W2Y4 in FASTA format

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