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UniProtKB/Swiss-Prot entry Q7YRB7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AOFB_CANFA
Primary accession number Q7YRB7
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 36)
Name and origin of the protein
Protein name Amine oxidase [flavin-containing] B
Synonyms EC 1.4.3.4
Monoamine oxidase type B
MAO-B
Gene name
Name: MAOB
From
Canis familiaris (Dog) [TaxID: 9615] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
TISSUE=Brain;
Hashizume C., Mori Y.;
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB070958; BAB86936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001002970.1; -.
UniGene Cfa.152
3D structure databases
HSSP P27338; 1OJA. [HSSP ENTRY / PDB]
SMR Q7YRB7; 3-500, 4-501.
ModBase Q7YRB7.
Ontologies
GO
GO:0005741; Cellular component: mitochondrial outer membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008131; Molecular function: amine oxidase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.
Pfam PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.
PRINTS PR00757; AMINEOXDASEF.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS Q7YRB7.
Genome annotation databases
Ensembl ENSCAFG00000014451; Canis familiaris. [Contig view]
GeneID 403451; -.
KEGG cfa:403451; -.
Phylogenomic databases
HOVERGEN Q7YRB7; -.
Other
ProtoNet Q7YRB7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   520  519     Amine oxidase [flavin-containing] B. PRO_0000099857
TOPO_DOM   2   489  488     Cytoplasmic (By similarity). 
TRANSMEM   490   516  27     Anchor for type IV membrane protein (By similarity). 
TOPO_DOM   517   520  4     Mitochondrial intermembrane (By similarity). 
COMPBIAS   36    52  17     Arg/Lys-rich (basic). 
SITE   156   156  1     Important for catalytic activity (By similarity). 
SITE   365   365  1     Important for catalytic activity (By similarity). 
SITE   382   382  1     Important for catalytic activity (By similarity). 
MOD_RES   2     2        N-acetylserine (By similarity). 
MOD_RES   52    52        N6-acetyllysine (By similarity). 
MOD_RES   397   397        S-8alpha-FAD cysteine (By similarity). 
Sequence information
Length: 520 AA [This is the length of the unprocessed precursor] Molecular weight: 58384 Da [This is the MW of the unprocessed precursor] CRC64: D5C6295875D7D8BE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSGKCDVVVV GGGISGMAAA KLLHDFGLNV VVLEARDRVG GRTYTIRNQK VKYLDLGGSY 

        70         80         90        100        110        120 
VGPTQNCILR LAKELGLETY KVNEVERLIH HVKGKSYPFR GPFPPVWNPI AYLDHNNLWR 

       130        140        150        160        170        180 
TMDDMGREIP SDAPWKAPLA EEWDHMTMKE LLDKICWTES AKQLATLFVN LCVTAETHEV 

       190        200        210        220        230        240 
SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVSER IMDLLGDQVK LERPVTHIDQ 

       250        260        270        280        290        300 
TGENVLVETL NHEVYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQLITRVP LGSVIKCIVY 

       310        320        330        340        350        360 
YKEPFWRKKD YCGTMIIEGE EAPIAYTLDD TKPDGNYAAI MGFILAHKAR KLARLTKDER 

       370        380        390        400        410        420 
MKKLCELYAK VLGSQEALQP VHYEEKNWCE EQYSGGCYTT YFPPGIMTQY GRVLRQPVGR 

       430        440        450        460        470        480 
IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAQPITTT 

       490        500        510        520 
FLERHLPSVP GLLRLIGLTA IFSATALGVL AHKRGLLVRV
Q7YRB7 in FASTA format

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