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UniProtKB/Swiss-Prot entry Q7Z895


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYD1_KLULA
Primary accession number Q7Z895
Secondary accession numbers None
Integrated into Swiss-Prot on August 31, 2004
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 39)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase
Synonyms DHOdehase
DHODase
DHOD
EC 1.3.3.1
Dihydroorotate oxidase
Gene name
Name: URA1
OrderedLocusNames: KLLA0C19360g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 200962 / CBS 141 / HA 714;
Hall C.R., Dietrich F.S.;
"Kluyveromyces lactis gene encoding the biosynthetic enzyme dihydroorotate dehydrogenase family 1a.";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY323896; AAQ01773.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR382123; CAH01915.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_453064.1; -.
3D structure databases
ModBase Q7Z895.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS Q7Z895.
Genome annotation databases
GeneID 2891827; -.
KEGG kla:KLLA0C19360g; -.
Phylogenomic databases
HOGENOM Q7Z895; -.
Other
ProtoNet Q7Z895.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   315  315     Dihydroorotate dehydrogenase. PRO_0000148500
ACT_SITE   133   133        Nucleophile (By similarity). 
Sequence information
Length: 315 AA [This is the length of the unprocessed precursor] Molecular weight: 34989 Da [This is the MW of the unprocessed precursor] CRC64: 46DAE6484E4A26A0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKPSLQVEFC GHIYENPLMN ASGVCCMTTN ELDDMARSSS GAFITKSATS MERDGNPEPR 

        70         80         90        100        110        120 
YVSVPLGSIN SMGLPNKGID YYLDYVLDRQ DRFPSENPPF MSVAGMSIDE NIKLLHRIQD 

       130        140        150        160        170        180 
SNFRGITELN LSCPNVPGKP QVAYDFELTD QILSSVFEFF TKPLGVKLPP YFDFAHFDAM 

       190        200        210        220        230        240 
ACILNKYPIA YVNCINSVGN GLYIDVEKES VVIKPKDGFG GIGGEYIKPT ALANVRAFYN 

       250        260        270        280        290        300 
RLNGRIRIIG TGGIKTGQDA FEHLLCGATM LQIGTELQNE GTEIFERINA ELLQILEQKG 

       310 
YQSIEDFRGK LRSIS 

Q7Z895 in FASTA format

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