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UniProtKB/Swiss-Prot entry Q828S5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_STRAW
Primary accession number Q828S5
Secondary accession numbers None
Integrated into Swiss-Prot on August 4, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: SAV_6587
From
Streptomyces avermitilis [TaxID: 33903] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165;
DOI=10.1073/pnas.211433198; PubMed=11572948 [NCBI, ExPASy, EBI, Israel, Japan]
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.";
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165;
DOI=10.1038/nbt820; PubMed=12692562 [NCBI, ExPASy, EBI, Israel, Japan]
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.;
"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.";
Nat. Biotechnol. 21:526-531(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000030; BAC74298.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_827763.1; -.
3D structure databases
ModBase Q828S5.
Enzyme and pathway databases
BioCyc SAVE227882:SAV6587-MON; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q828S5.
Genome annotation databases
GeneID 1211514; -.
GenomeReviews BA000030_GR; SAV_6587.
KEGG sma:SAV6587; -.
NMPDR fig|227882.1.peg.6589; -.
Phylogenomic databases
HOGENOM Q828S5; -.
Genome annotation databases
CMR Q828S5; SAV_6587.
Other
ProtoNet Q828S5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   438  438     Homogentisate 1,2-dioxygenase. PRO_0000220255
METAL   337   337        Iron (By similarity). 
METAL   343   343        Iron (By similarity). 
METAL   373   373        Iron (By similarity). 
Sequence information
Length: 438 AA [This is the length of the unprocessed precursor] Molecular weight: 47823 Da [This is the MW of the unprocessed precursor] CRC64: 8E751EBA9B6F53BC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSGDARKTAE GLAHLTGFGN EHASEAVPGA LPEGRNSPQR APLGLYAEQL SGSAFTEPRA 

        70         80         90        100        110        120 
HNRRSWLYRI RPSAAHPPFT RADNGAIRTA PFTETAPDPN RLRWNPLPEP PAGTDFVGGL 

       130        140        150        160        170        180 
WTLGGNGDAT QRTGMAVHLY HANSSMDRVF SDADGELLIV PERGGLLLRT EFGLLHAEPG 

       190        200        210        220        230        240 
QVALVPRGVR FRVDLLDESA RGYVCENYGA PFQLPDLGPI GANGLAAARD FKAPVAAYED 

       250        260        270        280        290        300 
VEGPVEVVNK FCGNLWTATY DHSPLDVVAW HGNHVPYTYD LRRFNVLGTI SYDHPDPSIF 

       310        320        330        340        350        360 
TVLTSPSDTP GLAGVDFVVF APRWLVGEDT FRPPYFHRNV MSEYMGLIEG AYDAKAAGFV 

       370        380        390        400        410        420 
PGGGSLHNMM SAHGPDRETF DRASAAELRP QKIDDGLAFM FETRWPVTAT AQAARAEHLQ 

       430 
PAYDDVWQGL QRHFRPSD
Q828S5 in FASTA format

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