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UniProtKB/Swiss-Prot entry Q845V3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BURM1
Primary accession number Q845V3
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
From
Burkholderia multivorans (strain ATCC 17616 / 249) [TaxID: 395019] 
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1128/JB.185.11.3333-3343.2003; PubMed=12754231 [NCBI, ExPASy, EBI, Israel, Japan]
Komatsu H., Imura Y., Ohori A., Nagata Y., Tsuda M.;
"Distribution and organization of auxotrophic genes on the multichromosomal genome of Burkholderia multivorans ATCC 17616.";
J. Bacteriol. 185:3333-3343(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB091436; BAC65270.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q845V3.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002035; VWF_A.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR00453; VWFADOMAIN.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q845V3.
Other
ProtoNet Q845V3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   438  438     Histidinol dehydrogenase. PRO_0000135749
ACT_SITE   335   335        Proton acceptor (By similarity). 
ACT_SITE   336   336        Proton acceptor (By similarity). 
METAL   267   267        Zinc (By similarity). 
METAL   270   270        Zinc (By similarity). 
METAL   369   369        Zinc (By similarity). 
METAL   428   428        Zinc (By similarity). 
BINDING   138   138        NAD (By similarity). 
BINDING   199   199        NAD (By similarity). 
BINDING   222   222        NAD (By similarity). 
BINDING   245   245        Substrate (By similarity). 
BINDING   267   267        Substrate (By similarity). 
BINDING   270   270        Substrate (By similarity). 
BINDING   336   336        Substrate (By similarity). 
BINDING   369   369        Substrate (By similarity). 
BINDING   423   423        Substrate (By similarity). 
BINDING   428   428        Substrate (By similarity). 
Sequence information
Length: 438 AA [This is the length of the unprocessed precursor] Molecular weight: 46607 Da [This is the MW of the unprocessed precursor] CRC64: 6D383BE84CDB5E25 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSITIRKLDS TSEGFDAALR AVLAFEASED EAIERSVAQI LADVKSRGDA AVLEYTNRFD 

        70         80         90        100        110        120 
RLNADSVAAL ELPQDALQAA LDGLEPKARG RAGSGCRTRA RYHEKQKIEC GTHSWQYTES 

       130        140        150        160        170        180 
DGTVLGQKIT PLDRVGLYVP GGKAAYPSSV LMNAIPARVA GVGEIVMVVP TPDGVKNDLV 

       190        200        210        220        230        240 
LAAALLGGVD RVFTIGGAQA VGALAYGTAT VPAVDKICGP GNAYVASAKR RVFGTVGIDM 

       250        260        270        280        290        300 
IAGPSEILVL CDGTTDPSWV AMDLFSQAEH DELAQSILLC PDASFIERVE KAIAELLPSM 

       310        320        330        340        350        360 
PRQDVIRASL EGRGALIKVR DMTEACRIAN DIAPEHLEIS ALEPQQWSQQ IRHAGAIFLG 

       370        380        390        400        410        420 
RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS LIEVSAEGAH TLGEIAAELA 

       430 
YGEGLQAHAK SAEFRMKG
Q845V3 in FASTA format

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