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UniProtKB/Swiss-Prot entry Q86A17


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHPR_DICDI
Primary accession number Q86A17
Secondary accession number Q559B3
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 33)
Name and origin of the protein
Protein name Dihydropteridine reductase
Synonyms EC 1.5.1.34
Quinoid dihydropteridine reductase
Gene name
Name: qdpr
ORFNames: DDB_0237752
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature00847; PubMed=12097910 [NCBI, ExPASy, EBI, Israel, Japan]
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC117176; AAO52138.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000008; EAL70979.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_644903.1; -.
3D structure databases
HSSP Q9XVJ3; 1OOE. [HSSP ENTRY / PDB]
ModBase Q86A17.
Organism-specific databases
dictyBase DDB0237752; qdpr.
Ontologies
GO
GO:0004155; Molecular function: 6,7-dihydropteridine reductase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006729; Biological process: tetrahydrobiopterin biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS Q86A17.
Genome annotation databases
GeneID 3396024; -.
KEGG ddi:DDBDRAFT_0168923; -.
Other
ProtoNet Q86A17.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase; Tetrahydrobiopterin biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   231  231     Dihydropteridine reductase. PRO_0000327797
NP_BIND   6    30  25     NADP (By similarity). 
ACT_SITE   138   138        Proton acceptor (By similarity). 
Sequence information
Length: 231 AA [This is the length of the unprocessed precursor] Molecular weight: 24651 Da [This is the MW of the unprocessed precursor] CRC64: 0D5E03DFF4F6AA14 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSKNILVLGG SGALGAEVVK FFKSKSWNTI SIDFRENPNA DHSFTIKDSG EEEIKSVIEK 

        70         80         90        100        110        120 
INSKSIKVDT FVCAAGGWSG GNASSDEFLK SVKGMIDMNL YSAFASAHIG AKLLNQGGLF 

       130        140        150        160        170        180 
VLTGASAALN RTSGMIAYGA TKAATHHIIK DLASENGGLP AGSTSLGILP VTLDTPTNRK 

       190        200        210        220        230 
YMSDANFDDW TPLSEVAEKL FEWSTNSDSR PTNGSLVKFE TKSKVTTWTN L 

Q86A17 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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