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UniProtKB/Swiss-Prot entry Q86VQ6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TRXR3_HUMAN
Primary accession number Q86VQ6
Secondary accession numbers Q6PIS8 Q9NNW6 Q9P101
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on February 26, 2008 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name Thioredoxin reductase 3
Synonyms EC 1.8.1.9
Thioredoxin reductase TR2
Thioredoxin and glutathione reductase
Gene name
Name: TXNRD3
Synonyms: TGR, TRXR3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 72-754.
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 176-754, AND SELENOCYSTEINE AT SEC-753.
DOI=10.1074/jbc.274.35.24522; PubMed=10455115 [NCBI, ExPASy, EBI, Israel, Japan]
Sun Q.-A., Wu Y., Zappacosta F., Jeang K.-T., Lee B.J., Hatfield D.L., Gladyshev V.N.;
"Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.";
J. Biol. Chem. 274:24522-24530(1999).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 178-754.
Miranda-Vizuete A.;
"TrxR3, a novel human thioredoxin reductase.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC024558; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC030028; AAH30028.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC050032; AAH50032.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF171055; AAD51325.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF133519; AAD39929.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Hs.477475
3D structure databases
HSSP O89049; 1H6V. [HSSP ENTRY / PDB]
SMR Q86VQ6; 194-676.
ModBase Q86VQ6.
Organism-specific databases
HGNC HGNC:20667; TXNRD3.
GenAtlas TXNRD3.
MIM 606235; gene. [NCBI / EBI]
PharmGKB PA134920642; -.
GeneCards Q86VQ6.
Gene expression databases
ArrayExpress Q86VQ6; -.
CleanEx HS_TXNRD3; -.
Ontologies
GO
GO:0004791; Molecular function: thioredoxin-disulfide reductase activity (non-traceable author statement from UniProtKB).
GO:0045454; Biological process: cell redox homeostasis (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR011767; GLR_AS.
IPR002109; Glutaredoxin.
IPR014025; Glutaredoxin_sub.
IPR011899; GRX_euk.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR006338; Reduct_Se.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 1.
PANTHER PTHR22912:SF23; Reduct_Se; 1.
Pfam PF00462; Glutaredoxin; 1.
PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00160; GLUTAREDOXIN.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR02180; GRX_euk; 1.
TIGR01438; TGR; 1.
PROSITE PS00195; GLUTAREDOXIN_1; FALSE_NEG.
PS51354; GLUTAREDOXIN_2; 1.
PS00076; PYRIDINE_REDOX_1; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q86VQ6.
ProtoNet Q86VQ6.
Genome annotation databases
Ensembl ENSG00000197763; Homo sapiens. [Contig view]
Phylogenomic databases
HOGENOM Q86VQ6; -.
HOVERGEN Q86VQ6; -.
Other
SOURCE TXNRD3; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Developmental protein; Differentiation; Electron transport; Endoplasmic reticulum; FAD; Flavoprotein; Microsome; NADP; Nucleus; Oxidoreductase; Redox-active center; Selenium; Selenocysteine; Spermatogenesis; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   754  754     Thioredoxin reductase 3. PRO_0000320695
DOMAIN   167   267  101     Glutaredoxin. 
NP_BIND   269   298  30     FAD (By similarity). 
ACT_SITE   727   727        Proton acceptor (By similarity). 
NON_STD   753   753        Selenocysteine. 
DISULFID   314   319        Redox-active (By similarity). 
CROSSLNK   752   753        Cysteinyl-selenocysteine (Cys-Sec) (By similarity). 
CONFLICT   72    72        V -> G (in Ref. 2; AAH50032). 
CONFLICT   176   177        RS -> AE (in Ref. 3; AAD51325). 
CONFLICT   357   357        T -> I (in Ref. 2; AAH30028). 
CONFLICT   448   448        T -> P (in Ref. 4; AAD39929). 
Sequence information
Length: 754 AA [This is the length of the unprocessed precursor] Molecular weight: 82464 Da [This is the MW of the unprocessed precursor] CRC64: 189F7C0C435277CF [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGHVHRLVSG KRRMHLTSRP VASTHSPLIL DMCPHLNNGP MTGCGRAGDP ISHARGGAGG 

        70         80         90        100        110        120 
RGERLPRGFA RVVRVASEGS VRRPSGPVPA PQPPAFRFVS RPGRARSESE TLERSPPQSP 

       130        140        150        160        170        180 
GPGKAGDAPN RRSGHVRGAR VLSPPGRRAR LSSPGPSRSS EAREELRRHL VGLIERSRVV 

       190        200        210        220        230        240 
IFSKSYCPHS TRVKELFSSL GVECNVLELD QVDDGARVQE VLSEITNQKT VPNIFVNKVH 

       250        260        270        280        290        300 
VGGCDQTFQA YQSGLLQKLL QEDLAYDYDL IIIGGGSGGL SCAKEAAILG KKVMVLDFVV 

       310        320        330        340        350        360 
PSPQGTSWGL GGTCVNVGCI PKKLMHQAAL LGQALCDSRK FGWEYNQQVR HNWETMTKAI 

       370        380        390        400        410        420 
QNHISSLNWG YRLSLREKAV AYVNSYGEFV EHHKIKATNK KGQETYYTAA QFVIATGERP 

       430        440        450        460        470        480 
RYLGIQGDKE YCITSDDLFS LPYCPGKTLV VGASYVALEC AGFLAGFGLD VTVMVRSILL 

       490        500        510        520        530        540 
RGFDQEMAEK VGSYMEQHGV KFLRKFIPVM VQQLEKGSPG KLKVLAKSTE GTETIEGVYN 

       550        560        570        580        590        600 
TVLLAIGRDS CTRKIGLEKI GVKINEKSGK IPVNDVEQTN VPYVYAVGDI LEDKPELTPV 

       610        620        630        640        650        660 
AIQSGKLLAQ RLFGASLEKC DYINVPTTVF TPLEYGCCGL SEEKAIEVYK KENLEIYHTL 

       670        680        690        700        710        720 
FWPLEWTVAG RENNTCYAKI ICNKFDHDRV IGFHILGPNA GEVTQGFAAA MKCGLTKQLL 

       730        740        750 
DDTIGIHPTC GEVFTTLEIT KSSGLDITQK GCUG 

Q86VQ6 in FASTA format

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