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UniProtKB/Swiss-Prot entry Q86WN2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IFNE_HUMAN
Primary accession number Q86WN2
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 51)
Name and origin of the protein
Protein name Interferon epsilon [Precursor]
Synonym Interferon epsilon-1
Gene name
Name: IFNE
Synonyms: IFNE1
ORFNames: UNQ360/PRO655
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1016/j.ygeno.2004.03.003; PubMed=15233997 [NCBI, ExPASy, EBI, Israel, Japan]
Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
"Characterization of the type I interferon locus and identification of novel genes.";
Genomics 84:331-345(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY190045; AAO38686.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358570; AAQ88933.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC100871; AAI00872.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC100872; AAI00873.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC100873; AAI00874.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00329100; -.
RefSeq NP_795372.1; -.
UniGene Hs.682604
3D structure databases
HSSP P56828; 1B5L. [HSSP ENTRY / PDB]
ModBase Q86WN2.
Organism-specific databases
GeneCards GC09M021470; -.
HGNC HGNC:18163; IFNE.
GenAtlas IFNE.
Gene expression databases
ArrayExpress Q86WN2; -.
Bgee Q86WN2; -.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0005125; Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005126; Molecular function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding (inferred from electronic annotation from InterPro).
GO:0006952; Biological process: defense response (inferred from electronic annotation from InterPro).
GO:0009615; Biological process: response to virus (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR012351; 4_helix_cytokine_core.
IPR000471; IInterferon_alpha/beta/delta.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
PANTHER PTHR11691; Interferon_abd; 1.
Pfam PF00143; Interferon; 1.
Pfam graphical view of domain structure.
PRINTS PR00266; INTERFERONAB.
ProDom PD000550; Interferon_abd; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00076; IFabd; 1.
SMART graphical view of domain structure.
PROSITE PS00252; INTERFERON_A_B_D; 1.
Genome annotation databases
Ensembl ENSG00000184995; Homo sapiens. [Contig view]
GeneID 338376; -.
KEGG hsa:338376; -.
Phylogenomic databases
HOGENOM Q86WN2; -.
HOVERGEN Q86WN2; -.
OMA Q86WN2; RIHDYLE.
Other
NextBio 96956; -.
ProtoNet Q86WN2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
CHAIN   22   208  187     Interferon epsilon. PRO_0000317631
CARBOHYD   95    95        N-linked (GlcNAc...) (Potential). 
CARBOHYD   104   104        N-linked (GlcNAc...) (Potential). 
DISULFID   53   163        By similarity. 
VARIANT   46    46  1     Q -> H (in dbSNP:rs1125488 [NCBI]). VAR_049639 
Sequence information
Length: 208 AA [This is the length of the unprocessed precursor] Molecular weight: 24414 Da [This is the MW of the unprocessed precursor] CRC64: 65FB861407F14E5F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF 

        70         80         90        100        110        120 
LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL 

       130        140        150        160        170        180 
EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF 

       190        200 
SLTEKLSKQG RPLNDMKQEL TTEFRSPR 

Q86WN2 in FASTA format

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