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UniProtKB/Swiss-Prot entry Q86WN2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IFNE1_HUMAN
Primary accession number Q86WN2
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Interferon epsilon-1 [Precursor]
Synonyms None
Gene name
Name: IFNE1
ORFNames: UNQ360/PRO655
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1016/j.ygeno.2004.03.003; PubMed=15233997 [NCBI, ExPASy, EBI, Israel, Japan]
Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
"Characterization of the type I interferon locus and identification of novel genes.";
Genomics 84:331-345(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY190045; AAO38686.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358570; AAQ88933.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC100871; AAI00872.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC100872; AAI00873.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC100873; AAI00874.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_795372.1; -.
UniGene Hs.682604
3D structure databases
HSSP P56828; 1B5L. [HSSP ENTRY / PDB]
ModBase Q86WN2.
Organism-specific databases
GeneCards Q86WN2.
Gene expression databases
ArrayExpress Q86WN2; -.
Family and domain databases
InterPro IPR012351; 4_helix_cytokine_core.
IPR000471; Interferon_abd.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
PANTHER PTHR11691; Interferon_abd; 1.
Pfam PF00143; Interferon; 1.
Pfam graphical view of domain structure.
PRINTS PR00266; INTERFERONAB.
ProDom PD000550; Interferon_abd; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00076; IFabd; 1.
SMART graphical view of domain structure.
PROSITE PS00252; INTERFERON_A_B_D; 1.
BLOCKS Q86WN2.
Genome annotation databases
Ensembl ENSG00000184995; Homo sapiens. [Contig view]
GeneID 338376; -.
KEGG hsa:338376; -.
Phylogenomic databases
HOGENOM Q86WN2; -.
HOVERGEN Q86WN2; -.
Other
LinkHub Q86WN2; -.
ProtoNet Q86WN2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antiviral defense; Cytokine; Glycoprotein; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
CHAIN   22   208  187     Interferon epsilon-1. PRO_0000317631
CARBOHYD   95    95        N-linked (GlcNAc...) (Potential). 
CARBOHYD   104   104        N-linked (GlcNAc...) (Potential). 
DISULFID   53   163        By similarity. 
Sequence information
Length: 208 AA [This is the length of the unprocessed precursor] Molecular weight: 24414 Da [This is the MW of the unprocessed precursor] CRC64: 65FB861407F14E5F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF 

        70         80         90        100        110        120 
LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL 

       130        140        150        160        170        180 
EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF 

       190        200 
SLTEKLSKQG RPLNDMKQEL TTEFRSPR 

Q86WN2 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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