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UniProtKB/Swiss-Prot entry Q873E8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHR_NEUCR
Primary accession number Q873E8
Secondary accession number Q1K529
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 31)
Name and origin of the protein
Protein name Glutathione reductase
Synonyms GRase
GR
EC 1.8.1.7
Gene name
Name: glr-1
ORFNames: B10C3.130, NCU03339
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1093/nar/gkg293; PubMed=12655011 [NCBI, ExPASy, EBI, Israel, Japan]
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX284749; CAD70360.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000008; EAA27212.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_956448.1; -.
3D structure databases
HSSP P00390; 3GRS. [HSSP ENTRY / PDB]
ModBase Q873E8.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006322; Glut_reduct_1.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01421; gluta_reduc_1; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
BLOCKS Q873E8.
Genome annotation databases
GeneID 3872613; -.
NMPDR fig|5141.1.peg.530; -.
Other
ProtoNet Q873E8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   468  468     Glutathione reductase. PRO_0000067969
NP_BIND   38    46  9     FAD (By similarity). 
ACT_SITE   457   457        Proton acceptor (By similarity). 
DISULFID   46    51        Redox-active (By similarity). 
Sequence information
Length: 468 AA [This is the length of the unprocessed precursor] Molecular weight: 50313 Da [This is the MW of the unprocessed precursor] CRC64: A3802C1A7DC0B479 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAPISRETDF LVIGGGSGGI ATARAAAGKY GIKSMVVEGK RLGGTCVNVG CVPKKVTFYA 

        70         80         90        100        110        120 
ALVAETIHQA KDYGFSVEQT APFDWPTFKQ KRDAYVARLN GIYERNLAND KVEYVHGWAK 

       130        140        150        160        170        180 
LLSPNSVEVT LDDGTKSVVN AKKILIAVGG NPTIPPHIPG SEYGTNSDGF FDIDTLPKKV 

       190        200        210        220        230        240 
ALVGAGYIAV EFAGMLNALG VETHLFIRHD TFLRSFDPMI QQVSVKEYER IGVKVHKKSQ 

       250        260        270        280        290        300 
LTSVQKDAAG KLAINFKEGE GEQSISDVDH LIWAVGRTPA VEGLGLDKAG VKTNEKGYIE 

       310        320        330        340        350        360 
VDEYQNTSTE NIYAVGDVCG QVELTPVAIA AGRKLAARLF GPEEFRTLKL NYDNVPSVVF 

       370        380        390        400        410        420 
AHPEIGSIGL TEPEAVAKYG AENLKIYKSS FTAMYYAMMK PEDKAPTAYK LICAGPEEKV 

       430        440        450        460 
VGLHIIGLGS GEILQGFGVA VNMGATKADF DNCVAIHPTS AEELVTLK 

Q873E8 in FASTA format

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