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UniProtKB/Swiss-Prot entry Q8BWF0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SSDH_MOUSE
Primary accession number Q8BWF0
Secondary accession number Q5SZW1
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name Succinate-semialdehyde dehydrogenase, mitochondrial [Precursor]
Synonyms EC 1.2.1.24
NAD(+)-dependent succinic semialdehyde dehydrogenase
Aldehyde dehydrogenase family 5 member A1
Gene name
Name: Aldh5a1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Kidney;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
The mouse genome sequencing consortium;
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
[3]
PROTEIN SEQUENCE OF 57-74; 115-123; 129-160; 162-172; 181-201; 254-289; 291-320; 323-333; 339-347; 401-436; 469-496 AND 507-516, AND MASS SPECTROMETRY.
STRAIN=C57BL/6;
TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[4]
PROTEIN SEQUENCE OF 401-418, AND MASS SPECTROMETRY.
TISSUE=Hippocampus;
Lubec G., Klug S.;
Submitted (MAR-2007) to UniProtKB.
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-67, AND MASS SPECTROMETRY.
TISSUE=Brain;
DOI=10.1021/pr0701254; PubMed=18034455 [NCBI, ExPASy, EBI, Israel, Japan]
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK052703; BAC35105.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK144030; BAE25663.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL589699; CAI26086.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_766120.1; -.
UniGene Mm.393311
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase Q8BWF0.
PTM databases
PhosphoSite Q8BWF0; -.
Organism-specific databases
MGI MGI:2441982; Aldh5a1.
Gene expression databases
ArrayExpress Q8BWF0; -.
CleanEx MM_ALDH5A1; -.
GermOnline ENSMUSG00000035936; Mus musculus.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from UniProtKB).
GO:0004777; Molecular function: succinate-semialdehyde dehydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006083; Biological process: acetate metabolic process (inferred from mutant phenotype from MGI).
GO:0007417; Biological process: central nervous system development (inferred from sequence or structural similarity from UniProtKB).
GO:0006681; Biological process: galactosylceramide metabolic process (inferred from mutant phenotype from MGI).
GO:0009450; Biological process: gamma-aminobutyric acid catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006006; Biological process: glucose metabolic process (inferred from mutant phenotype from MGI).
GO:0006678; Biological process: glucosylceramide metabolic process (inferred from mutant phenotype from MGI).
GO:0006536; Biological process: glutamate metabolic process (inferred from mutant phenotype from MGI).
GO:0006541; Biological process: glutamine metabolic process (inferred from mutant phenotype from MGI).
GO:0006749; Biological process: glutathione metabolic process (inferred from mutant phenotype from MGI).
GO:0006650; Biological process: glycerophospholipid metabolic process (inferred from mutant phenotype from MGI).
GO:0042135; Biological process: neurotransmitter catabolic process (inferred from mutant phenotype from MGI).
GO:0009791; Biological process: post-embryonic development (inferred from mutant phenotype from MGI).
GO:0022904; Biological process: respiratory electron transport chain (inferred from mutant phenotype from MGI).
GO:0006105; Biological process: succinate metabolic process (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010102; Succ_semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01780; SSADH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q8BWF0.
Genome annotation databases
Ensembl ENSMUSG00000035936; Mus musculus. [Contig view]
GeneID 214579; -.
KEGG mmu:214579; -.
NMPDR fig|10090.3.peg.27594; -.
Phylogenomic databases
HOGENOM Q8BWF0; -.
HOVERGEN Q8BWF0; -.
Other
SOURCE Aldh5a1; Mus musculus.
ProtoNet Q8BWF0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    35  35     Mitochondrion (By similarity). 
CHAIN   36   523  488     Succinate-semialdehyde dehydrogenase, mitochondrial. PRO_0000007185
NP_BIND   272   277  6     NADP (By similarity). 
ACT_SITE   294   294        Proton acceptor (By similarity). 
ACT_SITE   328   328        Nucleophile (By similarity). 
SITE   193   193  1     Transition state stabilizer (By similarity). 
MOD_RES   67    67        Phosphotyrosine. 
Sequence information
Length: 523 AA [This is the length of the unprocessed precursor] Molecular weight: 55968 Da [This is the MW of the unprocessed precursor] CRC64: E0CF82E4F4FAE9D0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATCFLLRSF WAARPALPPP GRFRPEPAGT PRRSYASGPG GLHADLLRGD SFVGGRWLPA 

        70         80         90        100        110        120 
PATFPVYDPA SGAKLGTVAD CGVPEARAAV RAAYDAFNSW KGVSVKERSL LLRKWYDLMI 

       130        140        150        160        170        180 
QNKDDLAKII TAESGKPLKE AQGEILYSAL FLEWFSEEAR RIYGDIIYTS AKDKRGLVLK 

       190        200        210        220        230        240 
QPVGVAAIIT PWNFPSAMIT RKVGAALAAG CTVVVKPAED TPYSALALAQ LANQAGIPAG 

       250        260        270        280        290        300 
VYNVIPCSRN KAKEVGEVLC TDPLVSKISF TGSTATGKIL LHHAANSVKR VSMELGGLAP 

       310        320        330        340        350        360 
FIVFDSANVD QAVAGAMASK FRNAGQTCVC SNRFLVQRGI HDSFVTKFAE AMKKSLRVGN 

       370        380        390        400        410        420 
GFEEGTTQGP LINEKAVEKV EKQVNDAVAK GATVVTGGKR HQSGGNFFEP TLLSNVTRDM 

       430        440        450        460        470        480 
LCITEETFGP LAPVIKFDKE EEAVAIANAA EVGLAGYFYS QDPAQIWRVA EQLEVGMVGV 

       490        500        510        520 
NEGLISSVEC PFGGVKQSGL GREGSKYGID EYLEVKYVCY GGL 

Q8BWF0 in FASTA format

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