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UniProtKB/Swiss-Prot entry Q8CFX1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PE_MOUSE
Primary accession number Q8CFX1
Secondary accession number Q8BLH1
Integrated into Swiss-Prot on May 30, 2006
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 42)
Name and origin of the protein
Protein name GDH/6PGL endoplasmic bifunctional protein [Precursor]
Synonyms None
Includes Glucose 1-dehydrogenase
     (EC 1.1.1.47)
     (Hexose-6-phosphate dehydrogenase)
6-phosphogluconolactonase
     (6PGL)
     (EC 3.1.1.31)
Gene name
Name: H6pd
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK045199; BAC32260.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK159373; BAE35029.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC042677; AAH42677.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_775547.2; -.
UniGene Mm.22183
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase Q8CFX1.
PTM databases
PhosphoSite Q8CFX1; -.
Organism-specific databases
MGI MGI:2140356; H6pd.
Gene expression databases
ArrayExpress Q8CFX1; -.
GermOnline ENSMUSG00000028980; Mus musculus.
Ontologies
GO
GO:0005792; Cellular component: microsome (inferred from direct assay from MGI).
GO:0017057; Molecular function: 6-phosphogluconolactonase activity (inferred from direct assay from MGI).
GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity (inferred from direct assay from MGI).
GO:0006098; Biological process: pentose-phosphate shunt (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR006148; Gluc_gal_isom.
IPR016040; NAD(P)-bd.
IPR005900; Phosphogluconlac.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 2.
PF01182; Glucosamine_iso; 1.
Pfam graphical view of domain structure.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01198; pgl; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS Q8CFX1.
Genome annotation databases
Ensembl ENSMUSG00000028980; Mus musculus. [Contig view]
GeneID 100198; -.
KEGG mmu:100198; -.
Phylogenomic databases
HOVERGEN Q8CFX1; -.
Other
SOURCE H6pd; Mus musculus.
ProtoNet Q8CFX1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Endoplasmic reticulum; Glucose metabolism; Glycoprotein; Hydrolase; Multifunctional enzyme; NAD; NADP; Oxidoreductase; Phosphoprotein; Pyrrolidone carboxylic acid; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    16  16     Potential. 
CHAIN   17   789  773     GDH/6PGL endoplasmic bifunctional protein. PRO_0000236794
REGION   17   524  508     Glucose 1-dehydrogenase. 
REGION   525   538  14     Linker. 
REGION   539   789  251     6-phosphogluconolactonase. 
ACT_SITE   264   264        Proton acceptor (By similarity). 
BINDING   31    31        NADP (By similarity). 
BINDING   63    63        NADP (By similarity). 
BINDING   201   201        Substrate (By similarity). 
BINDING   205   205        Substrate (By similarity). 
MOD_RES   17    17        Pyrrolidone carboxylic acid (By similarity). 
MOD_RES   313   313        Phosphotyrosine (By similarity). 
CARBOHYD   154   154        N-linked (GlcNAc...) (Potential). 
CARBOHYD   279   279        N-linked (GlcNAc...) (Potential). 
CARBOHYD   681   681        N-linked (GlcNAc...) (Potential). 
CONFLICT   77    77        A -> V (in Ref. 1; BAC32260). 
CONFLICT   106   106        H -> R (in Ref. 1; BAC32260). 
CONFLICT   285   285        T -> A (in Ref. 1; BAC32260). 
Sequence information
Length: 789 AA [This is the length of the unprocessed precursor] Molecular weight: 88911 Da [This is the MW of the unprocessed precursor] CRC64: 78C820EF38D81D2B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLLAAMCLAL LGCLQAQELK GHVSIILLGA TGDLAKKYLW QGLFQLYLDE AGKGHSFSFH 

        70         80         90        100        110        120 
GAALTAPQQG QKLMDKALES LSCPKDLVPS RCDELKGQFL QLSQYHQLKT VEDYQTLNKD 

       130        140        150        160        170        180 
IETQVQQDGL WEAGRIFYFS VPPFAYADIA RNINSSCRPH PGAWLRVVFE KPFGHDHLSA 

       190        200        210        220        230        240 
QQLASELGSF FQEEEMYRVD HYLGKQAVAQ ILPFRDQNRK ALDGLWNRHH VERVEIILKE 

       250        260        270        280        290        300 
TIDAEGRASF YEEYGVIRDT LQNHLTEILT LVAMELPLNI SSSATVLQHK LWAFQALRGL 

       310        320        330        340        350        360 
QKSSAILGQY QAYSGQVRRE LQKPDGFQSL TPTFAGVLVH IDNLRWEGVP FILMSGKALD 

       370        380        390        400        410        420 
ERVGYVRIVF KNRAYCTQSE RHWVPEQSRC LPQQIIFYIG HGELGHPAIL VSRNLFKPSL 

       430        440        450        460        470        480 
PTQKWKEVQD QPGLRLFGRP LSDYYAYRPV REQDAYSTLL SHIFHCRKES FITTENLLAS 

       490        500        510        520        530        540 
WVFWTPLLDS LAFEVPRPYP GGAENGQLLD FEFSGGQLTF SQQQLEVLIP DLGSVPKPSD 

       550        560        570        580        590        600 
FQVLGARYRQ SPLITAWPEE LISKLASDIE AAAVQAVRHF GKFHLALSGG SSPIALFQQL 

       610        620        630        640        650        660 
ATGHYSFPWA HTHLWLVDER CVPLSDPDSN FQGLQAHLLQ HVRVPYYNIH PMPVHLHQRL 

       670        680        690        700        710        720 
CAEEDQGAQT YASEISALVA NSSFDLVLLG MGTDGHTASL FPQSPTGLDG DQLVVLTESP 

       730        740        750        760        770        780 
FRPHQRMSLS LPLINRAKKV AVLVMGRTKR EITTLVSRVG HEPKKWPISG VVPLSGQLVW 


YMDYEAFLG 

Q8CFX1 in FASTA format

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