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UniProtKB/Swiss-Prot entry Q8FEI8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYSI_ECOL6
Primary accession number Q8FEI8
Secondary accession numbers None
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Sulfite reductase [NADPH] hemoprotein beta-component
Synonyms SIR-HP
SIRHP
EC 1.8.1.2
Gene name
Name: cysI
OrderedLocusNames: c3322
From
Escherichia coli O6 [TaxID: 217992] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
DOI=10.1073/pnas.252529799; PubMed=12471157 [NCBI, ExPASy, EBI, Israel, Japan]
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014075; AAN81771.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_755201.1; -.
3D structure databases
HSSP P17846; 2GEP. [HSSP ENTRY / PDB]
SMR Q8FEI8; 80-569, 81-570.
ModBase Q8FEI8.
Ontologies
GO
GO:0004783; Molecular function: sulfite reductase (NADPH) activity (inferred from electronic annotation from HAMAP).
GO:0000103; Biological process: sulfate assimilation (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01540; -; 1.
PBIL [Tree]
InterPro IPR011786; CysI.
IPR006066; Nir_Si_BS.
IPR006067; Nir_Sir_4Fe4S.
IPR005117; NiRdtase/SiRdtase_haem-b_fer.
Graphical view of domain structure.
Pfam PF01077; NIR_SIR; 1.
PF03460; NIR_SIR_ferr; 2.
Pfam graphical view of domain structure.
PRINTS PR00397; SIROHAEM.
TIGRFAMs TIGR02041; CysI; 1.
PROSITE PS00365; NIR_SIR; 1.
BLOCKS Q8FEI8.
Genome annotation databases
GeneID 1039153; -.
GenomeReviews AE014075_GR; c3322.
KEGG ecc:c3322; -.
NMPDR fig|199310.1.peg.3244; -.
Phylogenomic databases
HOGENOM Q8FEI8; -.
Genome annotation databases
CMR Q8FEI8; c3322.
Other
ProtoNet Q8FEI8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Heme; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   570  569     Sulfite reductase [NADPH] hemoprotein beta-component. PRO_0000199898
METAL   434   434        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   440   440        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   479   479        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   483   483        Iron (siroheme axial ligand) (By similarity). 
METAL   483   483        Iron-sulfur (4Fe-4S) (By similarity). 
Sequence information
Length: 570 AA [This is the length of the unprocessed precursor] Molecular weight: 63978 Da [This is the MW of the unprocessed precursor] CRC64: 5C35E78DFB0E433B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEKHPGPLV VEGKLTDAER MKLESNYLRG TIAEDLNDGL TGGFKGDNFL LIRFHGMYQQ 

        70         80         90        100        110        120 
DDRDIRAERA EQKLEPRHAM LLRCRLPGGV ITTKQWQAID KFAGENTIYG SIRLTNRQTF 

       130        140        150        160        170        180 
QFHGILKKNV KPVHQMLHSV GLDALATAND MNRNVLCTSN PYESQLHAEA YEWAKKISEH 

       190        200        210        220        230        240 
LLPRTRAYAE IWLDQEKVAT TDEEPILGQT YLPRKFKTTV VIPPQNDIDL HANDMNFVAI 

       250        260        270        280        290        300 
AENGKLVGFN LLVGGGLSIE HGNKKTYART ASEFGYLPLE HTLAVAEAVV TTQRDWGNRT 

       310        320        330        340        350        360 
DRKNAKTKYT LERVGVETFK AEVERRAGIK FEPIRPYEFT GRGDRIGWVK GIDDNWHLTL 

       370        380        390        400        410        420 
FIENGRILDY PGRPLKTGLL EIAKIHKGDF RITANQNLII AGVPESEKAK IEKIAKESGL 

       430        440        450        460        470        480 
MNAVTPQREN SMACVSFPTC PLAMAEAERF LPSFIDNIDN LMAKHGVSDE HIVMRVTGCP 

       490        500        510        520        530        540 
NGCGRAMLAE VGLVGKAPGR YNLHLGGNRM GTRIPRMYKE NITEPEILAS LDELIGRWAK 

       550        560        570 
EREAGEGFGD FTVRAGIIRP VLDPARDLWD
Q8FEI8 in FASTA format

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