[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain cortex; Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.; "Isolation and characterization of cDNA for macaque neurological disease genes."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity).
CATALYTIC ACTIVITY: Glutaryl-CoA + acceptor = crotonoyl-CoA + CO₂ + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amino-acid metabolism; lysine degradation .
PATHWAY: Amino-acid metabolism; tryptophan metabolism .
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix.
SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB083311; BAC20590.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P15651; 1JQI. [HSSP ENTRY / PDB]

SMR

Q8HXX8; 47-436.

ModBase

Q8HXX8.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006089; Acyl-CoA_DHase_CS.
IPR006092; Acyl-CoA_DHase_N.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.

Pfam

PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
PF02771; Acyl-CoA_dh_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00072; ACYL_COA_DH_1; 1.
PS00073; ACYL_COA_DH_2; 1.

BLOCKS

Q8HXX8.

Phylogenomic databases

HOVERGEN

Q8HXX8; -.

Other

ProtoNet

Q8HXX8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 44`	`44`	`Mitochondrion (Potential).`
`CHAIN`	`45 438`	`394`	`Glutaryl-CoA dehydrogenase, mitochondrial.`	`PRO_0000000527`
`ACT_SITE`	`414 414`		`Proton acceptor (Potential).`

Sequence information

Length: 438 AA [This is the length of the unprocessed precursor]

Molecular weight: 48382 Da [This is the MW of the unprocessed precursor]

CRC64: 7220D91CD65F263E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALRGVSVQL LSRVPGLRVF RTWVSSAAQT EKVGRTQSQL AKSSRPEFDW RDPLVLEEQL 

        70         80         90        100        110        120 
TTDEILIRDT FRTYCQERLM PRILLANRNE VFHREIISQM GELGVLGPTI KGYGCAGVSS 

       130        140        150        160        170        180 
VAYGLLAREL ERVDSGYRSA MSVQSPLVMH PIYAYGSEEQ RQKYLPRLAK GELLGCFGLT 

       190        200        210        220        230        240 
EPNSGSDPSS METRARYNSS NKSYTLNGTK TWITNSPMAD LFVVWARCED GRIRGFLLEK 

       250        260        270        280        290        300 
GMRGLSAPRI QGKFSLRASA TGMIIMDGVE VPEENMLPGA SSLGGSFGCL NNGRYGIAWG 

       310        320        330        340        350        360 
VLGASEFCLH TARQYALDRM QFGVPLARNQ LIQKKLADML TEITLGLHAC LQLGRLKDQD 

       370        380        390        400        410        420 
KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH 

       430 
ALILGRAITG IQAFTASK

Q8HXX8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools