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UniProtKB/Swiss-Prot entry Q8NI99


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ANGL6_HUMAN
Primary accession number Q8NI99
Secondary accession number Q9BZZ0
Integrated into Swiss-Prot on May 10, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Angiopoietin-related protein 6 [Precursor]
Synonyms Angiopoietin-like 6
Angiopoietin-related growth factor
Angiopoietin-related protein 5
Gene name
Name: ANGPTL6
Synonyms: AGF, ARP5
ORFNames: UNQ152/PRO178
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.1531901100; PubMed=12871997 [NCBI, ExPASy, EBI, Israel, Japan]
Oike Y., Yasunaga K., Ito Y., Matsumoto S., Maekawa H., Morisada T., Arai F., Nakagata N., Takeya M., Masuho Y., Suda T.;
"Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration.";
Proc. Natl. Acad. Sci. U.S.A. 100:9494-9499(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Samal B., Wu C., Dias P., Singh S.;
"Molecular cloning of a novel angiopoietin-related protein.";
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
Comments
  • FUNCTION: May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
  • SUBCELLULAR LOCATION: Secreted (Probable).
  • SIMILARITY: Contains 1 fibrinogen C-terminal domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB054064; BAB91248.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF230330; AAK06404.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358276; AAQ88643.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_114123.2; -.
UniGene Hs.699819
3D structure databases
HSSP P02671; 1FZD. [HSSP ENTRY / PDB]
ModBase Q8NI99.
Organism-specific databases
H-InvDB HIX0039936; -.
HGNC HGNC:23140; ANGPTL6.
GenAtlas ANGPTL6.
MIM 609336; gene. [NCBI / EBI]
PharmGKB PA134950669; -.
GeneCards Q8NI99.
Gene expression databases
CleanEx HS_ANGPTL6; -.
GermOnline ENSG00000130812; Homo sapiens.
Family and domain databases
InterPro IPR002181; Fibrinogen_a/b/g_C.
IPR014716; Fibrinogen_a/b/g_C_1.
Graphical view of domain structure.
Gene3D G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
Pfam PF00147; Fibrinogen_C; 1.
Pfam graphical view of domain structure.
SMART SM00186; FBG; 1.
SMART graphical view of domain structure.
PROSITE PS00514; FIBRIN_AG_C_DOMAIN; 1.
BLOCKS Q8NI99.
Genome annotation databases
Ensembl ENSG00000130812; Homo sapiens. [Contig view]
GeneID 83854; -.
KEGG hsa:83854; -.
Phylogenomic databases
HOGENOM Q8NI99; -.
HOVERGEN Q8NI99; -.
Other
SOURCE ANGPTL6; Homo sapiens.
ProtoNet Q8NI99.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Angiogenesis; Coiled coil; Developmental protein; Differentiation; Glycoprotein; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   470  450     Angiopoietin-related protein 6. PRO_0000009128
DOMAIN   258   468  211     Fibrinogen C-terminal. 
COILED   59   116  58     Potential. 
CARBOHYD   58    58        N-linked (GlcNAc...) (Potential). 
CARBOHYD   145   145        N-linked (GlcNAc...). 
DISULFID   260   287        By similarity. 
DISULFID   410   423        By similarity. 
CONFLICT   92    92        E -> K (in Ref. 2; AAK06404). 
Sequence information
Length: 470 AA [This is the length of the unprocessed precursor] Molecular weight: 51694 Da [This is the MW of the unprocessed precursor] CRC64: FAD20B1B00965239 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGKPWLRALQ LLLLLGASWA RAGAPRCTYT FVLPPQKFTG AVCWSGPAST RATPEAANAS 

        70         80         90        100        110        120 
ELAALRMRVG RHEELLRELQ RLAAADGAVA GEVRALRKES RGLSARLGQL RAQLQHEAGP 

       130        140        150        160        170        180 
GAGPGADLGA EPAAALALLG ERVLNASAEA QRAAARFHQL DVKFRELAQL VTQQSSLIAR 

       190        200        210        220        230        240 
LERLCPGGAG GQQQVLPPPP LVPVVPVRLV GSTSDTSRML DPAPEPQRDQ TQRQQEPMAS 

       250        260        270        280        290        300 
PMPAGHPAVP TKPVGPWQDC AEARQAGHEQ SGVYELRVGR HVVSVWCEQQ LEGGGWTVIQ 

       310        320        330        340        350        360 
RRQDGSVNFF TTWQHYKAGF GRPDGEYWLG LEPVYQLTSR GDHELLVLLE DWGGRGARAH 

       370        380        390        400        410        420 
YDGFSLEPES DHYRLRLGQY HGDAGDSLSW HNDKPFSTVD RDRDSYSGNC ALYQRGGWWY 

       430        440        450        460        470 
HACAHSNLNG VWHHGGHYRS RYQDGVYWAE FRGGAYSLRK AAMLIRPLKL 

Q8NI99 in FASTA format

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