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UniProtKB/Swiss-Prot entry Q8SPK1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP4AO_PIG
Primary accession number Q8SPK1
Secondary accession numbers Q70BW1 Q70BZ6
Integrated into Swiss-Prot on March 20, 2007
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 36)
Name and origin of the protein
Protein name Cytochrome P450 4A24
Synonyms EC 1.14.15.3
CYPIVA24
Fatty acid omega-hydroxylase
Gene name
Name: CYP4A24
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1042/0264-6021:3630297; PubMed=11931657 [NCBI, ExPASy, EBI, Israel, Japan]
Lundell K.;
"Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25].";
Biochem. J. 363:297-303(2002).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 83-448.
DOI=10.1042/BJ20031657; PubMed=14641109 [NCBI, ExPASy, EBI, Israel, Japan]
Lundell K.;
"The porcine taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21) gene: evolution by gene duplication and gene conversion.";
Biochem. J. 378:1053-1058(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ318096; CAC85662.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ586860; CAE52547.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ586619; CAE52533.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Ssc.49966
3D structure databases
HSSP P14779; 1JPZ. [HSSP ENTRY / PDB]
ModBase Q8SPK1.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q8SPK1.
Phylogenomic databases
HOVERGEN Q8SPK1; -.
Other
ProtoNet Q8SPK1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   504  504     Cytochrome P450 4A24. PRO_0000280743
TRANSMEM   6    26  21     Potential. 
TRANSMEM   112   132  21     Potential. 
METAL   451   451        Iron (heme axial ligand) (By similarity). 
CONFLICT   202   202        A -> V (in Ref. 2; CAE52533). 
CONFLICT   224   224        I -> T (in Ref. 2; CAE52533). 
CONFLICT   246   246        N -> S (in Ref. 2; CAE52533). 
CONFLICT   293   293        R -> Q (in Ref. 2; CAE52533). 
CONFLICT   382   384        GVS -> SVG (in Ref. 2; CAE52533). 
CONFLICT   404   404        T -> I (in Ref. 2; CAE52533). 
Sequence information
Length: 504 AA [This is the length of the unprocessed precursor] Molecular weight: 57199 Da [This is the MW of the unprocessed precursor] CRC64: DB7F815966DA7D7B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVPALASAS GLLQVASLLG LLLLLLKAAQ LYLHRQWLLK ALQQFPSPPS HWLYGHSREF 

        70         80         90        100        110        120 
QEESELPPLL KRVEKYPSAC ALWRWGTRAM VLVYDPDYMK VVLARSDPKN SVVYRLLIPW 

       130        140        150        160        170        180 
IGCGLLLLNG QTWFQRRRML TPAFHYDILK PYVGLMAKSV QVMLDKWEQL VAQDPRLEIV 

       190        200        210        220        230        240 
GPVSLMTLDT IMKCAFSHQG SAQTDGDSHS YIQAIWDLKN LFSIRTKSAF LQNDIIYRLS 

       250        260        270        280        290        300 
PEGRKNHRAA RIAHQHTDRV IQLRKAQLQK QGEMENVRKK RHLDFLDILL LARMEKGNSL 

       310        320        330        340        350        360 
SDTDLRAEVD TFMFEGHDTT ASGISWILYA LASHPEHQQR CREEIQGLLG DGTSITWDHL 

       370        380        390        400        410        420 
DQMPYTTMCI KEALRLYPPV PGVSRELSKP ITFPDGRSLP AGITLSLSIY GLHHNPQVWP 

       430        440        450        460        470        480 
NPEEFDPSRF APGSARHSHA FMPFSGGSRN CIGKQFAMNE MKVAVALTLL RFELAPDPSR 

       490        500 
KPIATPEVVL NSKNGIHLKL RKLP
Q8SPK1 in FASTA format

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