[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.; "The complete sequence of the Pyrococcus furiosus genome."; Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidation of L-aspartate to iminoaspartate.
CATALYTIC ACTIVITY: L-aspartate + H₂O + O₂ = oxaloacetate + NH₃ + H₂O₂.
COFACTOR: FAD.
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE010291; AAL82100.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_579705.1; -.

3D structure databases

HSSP

P10902; 1CHU. [HSSP ENTRY / PDB]

ModBase

Q8TZL4.

Family and domain databases

InterPro

IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR005288; NadB.
IPR001100; Pyr_nuc-diS_OxRdtase.
Graphical view of domain structure.

Pfam

PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00368; FADPNR.
PR00411; PNDRDTASEI.

TIGRFAMs

TIGR00551; nadB; 1.

BLOCKS

Q8TZL4.

Genome annotation databases

1469858; -.

AE009950_GR; PF1976.

pfu:PF1976; -.

fig|186497.1.peg.2028; -.

Phylogenomic databases

HOGENOM

Q8TZL4; -.

Genome annotation databases

CMR

Q8TZL4; PF1976.

Other

ProtoNet

Q8TZL4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; FAD; Flavoprotein; Oxidoreductase; Pyridine nucleotide biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 464`	`464`	`L-aspartate oxidase.`	`PRO_0000184409`
`NP_BIND`	`4 18`	`15`	`FAD (Potential).`
`ACT_SITE`	`210 210`		`By similarity.`
`ACT_SITE`	`227 227`		`By similarity.`

Sequence information

Length: 464 AA [This is the length of the unprocessed precursor]

Molecular weight: 51710 Da [This is the MW of the unprocessed precursor]

CRC64: 413C23A61594A7B3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKVAVVGSGL AGLTAAMSLA KKGIEVTVFG PKPKESNSYL AQAGIAFPIS DGDSIISHVT 

        70         80         90        100        110        120 
DTIRGGKYLN DVTVVWNVIS KSTEAYHFLT SLGIEFTSRE LEGGHSFPRI FTIKNETGKY 

       130        140        150        160        170        180 
IIPVLEKHAK EMGVNFIRKF AEEVAIHNKK IVGVFVEGEL LYFDAVIIAS GGFSGLYKFT 

       190        200        210        220        230        240 
AGNPWNLGIP IGDLALKGVP LRDIEFIQFH PTGFIGKRTY LISEAVRGAG AKLVTGEGER 

       250        260        270        280        290        300 
FVNELETRDV VAREIYRKML EGKGVFLDAT GIEDFKRRFP YIYSFLRREG INPKRDLIPV 

       310        320        330        340        350        360 
TPVAHYTIGG ISVDIFYRTP IKGLYAIGEA ACNGFHGANR LASNSLLECI VSGIEVSRTV 

       370        380        390        400        410        420 
IREKPRGERK EAKYHGYEPG NVDEVRDIMW NHAGIIRREE SLRLGLKKLE KVEADPRVKI 

       430        440        450        460 
LAEAVLKCAL AREESRGAHY REDYPYSREE FRRPSIFRVE NCML

Q8TZL4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools