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UniProtKB/Swiss-Prot entry Q8VSR0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYSI_ACTPL
Primary accession number Q8VSR0
Secondary accession number Q8VSQ9
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name Sulfite reductase [NADPH] hemoprotein beta-component
Synonyms SIR-HP
SIRHP
EC 1.8.1.2
Gene name
Name: cysI
From
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae) [TaxID: 715] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Actinobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=AP213 / Serotype 5a, and AP37 / Serotype 1;
PubMed=11768126 [NCBI, ExPASy, EBI, Israel, Japan]
Willson P.J., Gerlach G.F., Klashinsky S., Potter A.A.;
"Cloning and characterization of the gene coding for NADPH-sulfite reductase hemoprotein from Actinobacillus pleuropneumoniae and use of the protein product as a vaccine.";
Can. J. Vet. Res. 65:206-212(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF378783; AAL48202.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF378784; AAL48203.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P17846; 1AOP. [HSSP ENTRY / PDB]
ModBase Q8VSR0.
Ontologies
GO
GO:0004783; Molecular function: sulfite reductase (NADPH) activity (inferred from electronic annotation from HAMAP).
GO:0000103; Biological process: sulfate assimilation (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01540; -; 1.
PBIL [Tree]
InterPro IPR011786; CysI.
IPR006066; Nir_Si_BS.
IPR006067; Nir_Sir_4Fe4S.
IPR005117; NiRdtase/SiRdtase_haem-b_fer.
Graphical view of domain structure.
Pfam PF01077; NIR_SIR; 1.
PF03460; NIR_SIR_ferr; 2.
Pfam graphical view of domain structure.
PRINTS PR00397; SIROHAEM.
TIGRFAMs TIGR02041; CysI; 1.
PROSITE PS00365; NIR_SIR; 1.
BLOCKS Q8VSR0.
Other
ProtoNet Q8VSR0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Amino-acid biosynthesis; Cysteine biosynthesis; Heme; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   588  588     Sulfite reductase [NADPH] hemoprotein beta-component. PRO_0000199892
METAL   442   442        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   448   448        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   487   487        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   491   491        Iron (siroheme axial ligand) (By similarity). 
METAL   491   491        Iron-sulfur (4Fe-4S) (By similarity). 
VARIANT   35    35  1     E -> D (in strain: AP213). 
VARIANT   40    40  1     G -> D (in strain: AP213). 
VARIANT   199   199  1     I -> V (in strain: AP213). 
VARIANT   218   218  1     F -> Y (in strain: AP213). 
VARIANT   250   250  1     D -> E (in strain: AP213). 
VARIANT   319   319  1     I -> V (in strain: AP213). 
VARIANT   373   373  1     G -> V (in strain: AP213). 
VARIANT   523   523  1     P -> S (in strain: AP213). 
Sequence information
Length: 588 AA [This is the length of the unprocessed precursor] Molecular weight: 66683 Da [This is the MW of the unprocessed precursor] CRC64: 4CFE8C935664B2C2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSDKKIKGLE WQEKPLSDNE RLKTDSNFLR GTILEDLKDG LTGGFKGDNF QLIRFHGMYE 

        70         80         90        100        110        120 
QDDRDIRAER LEEKLEPLKF MLLRCRLPGG IIKPYQWIEI DKFAREHTRY QSIRLTNRQT 

       130        140        150        160        170        180 
FQYHGVPKGK LQPMHRLLHS IGLDSIATAA DMNRNVLCTS NPIESELHQQ AYEFAKKISE 

       190        200        210        220        230        240 
HLLPRSRGYL DVWVDGKKIE SSDDLLKIED EPILGKTFLP RKFKTAVAIP PLNDVDVYAN 

       250        260        270        280        290        300 
DLNFIAIQDD NGQLCGFNVL VGGGLSFEHG NTKTYPNVAY SLGFVPLEHT LAAAEGVVKT 

       310        320        330        340        350        360 
QRDFGNRSDR KNARVRYTIQ NMTLDGFRAE VERCMNIKFE PTRPYEFTER GDRIGWVKGI 

       370        380        390        400        410        420 
DNNWHLTLFI ESGRITDKPE KPLMTGVLEL AKVHKGDFRI TANQNLIVAN VAEQDKAQIE 

       430        440        450        460        470        480 
AIARQYGLIQ EISKLRENAM SCVSLPTCPL AMAEAERVLP DFISELDKVL SKHNVADESI 

       490        500        510        520        530        540 
ITRITGCPNG CGRAMLAEIG LVGKAIGRYN LHIGGDRAGL RIPRLYKENI TLQEIVNEID 

       550        560        570        580 
QLVARWATER QTNEAFGDFV IRSNIIAPVV NAHIDFWDAT KIIPTTII
Q8VSR0 in FASTA format

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