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UniProtKB/Swiss-Prot entry Q8YHJ4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name QUEF_BRUME
Primary accession number Q8YHJ4
Secondary accession numbers None
Integrated into Swiss-Prot on November 22, 2005
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name NADPH-dependent 7-cyano-7-deazaguanine reductase
Synonyms EC 1.7.1.13
7-cyano-7-carbaguanine reductase
PreQ(0) reductase
NADPH-dependent nitrile oxidoreductase
Gene name
Name: queF
OrderedLocusNames: BMEI0804
From
Brucella melitensis [TaxID: 29459] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=16M / ATCC 23456 / NCTC 10094 / Biotype 1;
DOI=10.1073/pnas.221575398; PubMed=11756688 [NCBI, ExPASy, EBI, Israel, Japan]
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R.;
"The genome sequence of the facultative intracellular pathogen Brucella melitensis.";
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009522; AAL51985.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AF3352; AF3352.
RefSeq NP_539721.1; -.
3D structure databases
ModBase Q8YHJ4.
Enzyme and pathway databases
BioCyc BMEL224914:BMEI0804-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003934; Molecular function: GTP cyclohydrolase I activity (inferred from electronic annotation from InterPro).
GO:0046857; Molecular function: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor (inferred from electronic annotation from HAMAP).
GO:0033739; Molecular function: queuine synthase activity (inferred from electronic annotation from EC).
GO:0019438; Biological process: aromatic compound biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0008616; Biological process: queuosine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00818; -; 1.
PBIL [Tree]
InterPro IPR016856; CN_OxRdtase_NADPH-dep_QueF.
IPR001474; GTP_CycOHase_I.
Graphical view of domain structure.
Pfam PF01227; GTP_cyclohydroI; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF027377; Nitrile_oxidored_QueF; 1.
TIGRFAMs TIGR03139; QueF-II; 1.
ProtoNet Q8YHJ4.
Genome annotation databases
GeneID 1196515; -.
GenomeReviews AE008917_GR; BMEI0804.
KEGG bme:BMEI0804; -.
Phylogenomic databases
HOGENOM Q8YHJ4; -.
Genome annotation databases
CMR Q8YHJ4; BMEI0804.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NADP; Oxidoreductase; Queuosine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   155  155     NADPH-dependent 7-cyano-7-deazaguanine reductase. PRO_0000162965
Sequence information
Length: 155 AA [This is the length of the unprocessed precursor] Molecular weight: 17402 Da [This is the MW of the unprocessed precursor] CRC64: BEC57D5171BBC051 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSENTIYSGL KQLGSHTDIP LTPEEAVLER VANPQEGTPY CVRFTAPEFS SLCPMTGQPD 

        70         80         90        100        110        120 
FAHLVIDYVP GKWLVESKSL KLFLFSFRNH GAFHEDCTVT IGKRLVDLLE PEWLRIGGYW 

       130        140        150 
YPRGGIPIDV FYQTGAAPLN VWIPEQGVAN YRGRG
Q8YHJ4 in FASTA format

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