ID   LLDD_YERPE              Reviewed;         381 AA.
AC   Q8ZFV8; Q0WGK6; Q74V74; Q7CHT1;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-NOV-2008, entry version 49.
DE   RecName: Full=L-lactate dehydrogenase [cytochrome];
DE            EC=1.1.2.3;
GN   Name=lldD; OrderedLocusNames=YPO1569, y2596, YP_1457;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   MEDLINE=21470413; PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA   Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA   Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA   Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   MEDLINE=22137863; PubMed=12142430;
RX   DOI=10.1128/JB.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA   Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA   Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA   Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA   Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA   Yang H., Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- CATALYTIC ACTIVITY: (S)-lactate + 2 ferricytochrome c = pyruvate +
CC       2 ferrocytochrome c + 2 H(+).
CC   -!- COFACTOR: FMN (By similarity).
CC   -!- SIMILARITY: Belongs to the FMN-dependent alpha-hydroxy acid
CC       dehydrogenase family.
CC   -!- SIMILARITY: Contains 1 FMN hydroxy acid dehydrogenase domain.
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DR   EMBL; AL590842; CAL20214.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM86151.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS61696.1; -; Genomic_DNA.
DR   PIR; AD0191; AD0191.
DR   RefSeq; NP_669900.1; -.
DR   RefSeq; NP_992819.1; -.
DR   HSSP; P05414; 1GOX.
DR   GeneID; 1147543; -.
DR   GeneID; 2767186; -.
DR   GenomeReviews; AE009952_GR; y2596.
DR   GenomeReviews; AE017042_GR; YP_1457.
DR   GenomeReviews; AL590842_GR; YPO1569.
DR   KEGG; ype:YPO1569; -.
DR   KEGG; ypk:y2596; -.
DR   KEGG; ypm:YP_1457; -.
DR   HOGENOM; Q8ZFV8; -.
DR   BioCyc; YPES187410:Y2596-MON; -.
DR   BioCyc; YPES214092:YPO1569-MON; -.
DR   BioCyc; YPES229193:YP1457-MON; -.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0004460; F:L-lactate dehydrogenase (cytochrome) activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01559; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012133; Alpha_OHA_DHase_FMN.
DR   InterPro; IPR008259; FMN_hydac_DHase_AS.
DR   InterPro; IPR000262; FMN_OHA_DHase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01070; FMN_dh; 1.
DR   PIRSF; PIRSF000138; Al-hdrx_acd_dh; 1.
DR   PROSITE; PS00557; FMN_HYDROXY_ACID_DH_1; 1.
DR   PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Flavoprotein; FMN; Oxidoreductase.
FT   CHAIN         1    381       L-lactate dehydrogenase [cytochrome].
FT                                /FTId=PRO_0000206359.
FT   DOMAIN        1    380       FMN hydroxy acid dehydrogenase.
FT   NP_BIND     306    330       FMN (By similarity).
FT   ACT_SITE    275    275       Proton acceptor (By similarity).
FT   BINDING      24     24       Substrate (Potential).
FT   BINDING     106    106       FMN (By similarity).
FT   BINDING     127    127       FMN (By similarity).
FT   BINDING     129    129       Substrate (By similarity).
FT   BINDING     155    155       FMN (By similarity).
FT   BINDING     164    164       Substrate (By similarity).
FT   BINDING     251    251       FMN (By similarity).
FT   BINDING     278    278       Substrate (Potential).
SQ   SEQUENCE   381 AA;  41259 MW;  ECC708A08D5E4634 CRC64;
     MIISASTDYR AAAQRKLPPF LFHYIDGGAY NEQTLRRNTA DLADIALRQR VLKNMSELSL
     ETQLFGETQA MPVVLGPVGL SGMYARRGEV QAARAADKKG IPFTLSTLSV CPIEEVAPAI
     ARPMWFQLYV LKDRGFMRNA LTRAQAAGVK TLVFTVDMPV PGARYRDAHS GMSGPNAAAR
     RLLQAIAHPQ WAWDVGLNGK PHDLGNISAY LGKPTTLEDY MGWIATNFDP SISWKDLEWV
     REFWQGPMII KGILDPEDAK DAVKFGADGI VVSNHGGRQL DGVLSTARAL PAIADAVKGD
     ITILADSGIR TGLDVVRMIA LGADSVLLGR AFVYALATAG EAGVINLLTL IEQEMRVAMT
     LTGAKRIADI NRDSLAVSER G
//