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UniProtKB/Swiss-Prot entry Q91YR9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PTGR1_MOUSE
Primary accession number Q91YR9
Secondary accession numbers Q3TKT6 Q9CPS1
Integrated into Swiss-Prot on August 16, 2005
Sequence was last modified on August 16, 2005 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name Prostaglandin reductase 1
Synonyms PRG-1
EC 1.3.1.-
NADP-dependent leukotriene B4 12-hydroxydehydrogenase
EC 1.3.1.74
15-oxoprostaglandin 13-reductase
EC 1.3.1.48
Gene name
Name: Ptgr1
Synonyms: Ltb4dh
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Embryo, Liver, Testis, and Urinary bladder;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK010888; BAB27248.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK011962; BAB27941.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK035425; BAC29060.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK134440; BAE22145.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK166835; BAE39057.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014865; AAH14865.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_080244.1; -.
UniGene Mm.34497
3D structure databases
HSSP P96202; 1PQW. [HSSP ENTRY / PDB]
SMR Q91YR9; 1-329.
ModBase Q91YR9.
PTM databases
PhosphoSite Q91YR9; -.
2D gel databases
REPRODUCTION-2DPAGE Q91YR9; -.
Organism-specific databases
MGI MGI:1914353; Ltb4dh.
Gene expression databases
ArrayExpress Q91YR9; -.
GermOnline ENSMUSG00000028378; Mus musculus.
Family and domain databases
InterPro IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR014190; B4_12hDHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02825; B4_12hDH; 1.
BLOCKS Q91YR9.
Genome annotation databases
Ensembl ENSMUSG00000028378; Mus musculus. [Contig view]
GeneID 67103; -.
KEGG mmu:67103; -.
Phylogenomic databases
HOGENOM Q91YR9; -.
HOVERGEN Q91YR9; -.
Other
SOURCE Ptgr1; Mus musculus.
ProtoNet Q91YR9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   329  329     Prostaglandin reductase 1. PRO_0000218066
NP_BIND   149   166  18     NADP (Potential). 
BINDING   178   178        NADP (By similarity). 
BINDING   193   193        NADP (By similarity). 
BINDING   217   217        NADP (By similarity). 
BINDING   245   245        NADP (By similarity). 
BINDING   321   321        NADP (By similarity). 
CONFLICT   298   298        C -> Y (in Ref. 2; AAH14865). 
CONFLICT   301   301        Y -> H (in Ref. 2; AAH14865). 
Sequence information
Length: 329 AA [This is the length of the unprocessed precursor] Molecular weight: 35560 Da [This is the MW of the unprocessed precursor] CRC64: FD0CA4682DB493D8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVQAKSWTLK KHFEGFPTDG NFELKTTELP PLNNGEVLLE ALFLSVDPYM RVAAKKLKEG 

        70         80         90        100        110        120 
DRMMGEQVAR VVESKNSAFP KGTIVAALLG WTSHSISDGN GLTKLPVEWP DKLPLSLALG 

       130        140        150        160        170        180 
TVGMPGLTAY FGLLDICGVK GGETVMVSAA AGAVGSVVGQ IAKLKGCKVV GTAGSDEKVA 

       190        200        210        220        230        240 
YLKKLGFDVA FNYKTVKSLE EALRTASPDG YDCYFDNVGG EFSNAVILQM KTFGRIAICG 

       250        260        270        280        290        300 
AISQYNRTGP CPQGPAPEVV IYQQLRMEGF IVNRWQGEVR QKALTELMNW VSEGKVQCHE 

       310        320 
YVTEGFEKMP AAFMGMLKGE NLGKTIVKA 

Q91YR9 in FASTA format

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