[1]	NUCLEOTIDE SEQUENCE [MRNA]. Tomitsuka E., Kita K.; "Complex II from rat mitochondria."; Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
[2]	PROTEIN SEQUENCE OF 39-67; 225-238; 354-371 AND 444-457, AND MASS SPECTROMETRY. STRAIN=Sprague-Dawley; TISSUE=Spinal cord; Lubec G., Afjehi-Sadat L.; Submitted (NOV-2006) to UniProtKB.

Comments

FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: FAD (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
MISCELLANEOUS: The complex, present in mitochondria, can be degraded to form EC 1.3.99.1, which no longer reacts with ubiquinone.
SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB072907; BAB69818.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_569112.1; -.

UniGene

Rn.101725

3D structure databases

HSSP

P10444; 1NEK. [HSSP ENTRY / PDB]

SMR

Q920L2; 45-656.

ModBase

Q920L2.

Protein-protein interaction databases

IntAct

Q920L2; -.

PTM databases

PhosphoSite

Q920L2; -.

Organism-specific databases

RGD

621557; Sdha.

Gene expression databases

ArrayExpress

Q920L2; -.

GermOnline

ENSRNOG00000013331; Rattus norvegicus.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0000104;	Molecular function: succinate dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.

Pfam

PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00368; FADPNR.
PR00411; PNDRDTASEI.

TIGRFAMs

TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.

PROSITE

PS00504; FRD_SDH_FAD_BINDING; 1.

BLOCKS

Q920L2.

Genome annotation databases

Ensembl

ENSRNOG00000013331; Rattus norvegicus. [Contig view]

GeneID

157074; -.

KEGG

rno:157074; -.

NMPDR

fig|10116.3.peg.337; -.

Phylogenomic databases

HOVERGEN

Q920L2; -.

Other

ProtoNet

Q920L2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Phosphoprotein; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 35`	`35`	`Mitochondrion (By similarity).`
`CHAIN`	`36 656`	`621`	`Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial.`	`PRO_0000010338`
`NP_BIND`	`83 98`	`16`	`FAD (By similarity).`
`ACT_SITE`	`332 332`		`Proton acceptor (By similarity).`
`BINDING`	`288 288`		`Substrate (By similarity).`
`BINDING`	`300 300`		`Substrate (By similarity).`
`BINDING`	`399 399`		`Substrate (By similarity).`
`BINDING`	`443 443`		`Substrate (By similarity).`
`MOD_RES`	`91 91`		`Tele-8alpha-FAD histidine (By similarity).`
`MOD_RES`	`171 171`		`N6-acetyllysine (By similarity).`
`MOD_RES`	`244 244`		`Phosphothreonine (By similarity).`
`MOD_RES`	`415 415`		`N6-acetyllysine (By similarity).`
`MOD_RES`	`477 477`		`N6-acetyllysine (By similarity).`
`MOD_RES`	`490 490`		`N6-acetyllysine (By similarity).`
`MOD_RES`	`530 530`		`N6-acetyllysine (By similarity).`

Sequence information

Length: 656 AA [This is the length of the unprocessed precursor]

Molecular weight: 71615 Da [This is the MW of the unprocessed precursor]

CRC64: 9E820F7FF7EC3B36 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGVGAVSRL LRGRRLALAG ATRGFHFSVG ESKKASAKVS DAISTQYPVV DHEFDAVVVG 

        70         80         90        100        110        120 
AGGAGLRAAF GLSEAGFNTA CLTKLFPTRS HTVAAQGGIN AALGNMEEDN WRWHFYDTVK 

       130        140        150        160        170        180 
GSDWLGDQDA IHYMTEQAPA SVVELENYGM PFSRTEDGRI YQRAFGGQSL KFGKGGQAHR 

       190        200        210        220        230        240 
CCCVADRTGH SLLHTLYGRS LRYDTSYFVE YFALDLLMEN GECRGVIALC IEDGSIHRIR 

       250        260        270        280        290        300 
AKNTIIATGG YGRTYFSCTS AHTSTGDGTA MVTRAGLPCQ DLEFVQFHPT GIYGAGCLIT 

       310        320        330        340        350        360 
EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT LEIREGRGCG PEKDHVYLQL 

       370        380        390        400        410        420 
HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY NMGGIPTNYK GQVLKHVNGQ 

       430        440        450        460        470        480 
DQIVPGLYAC GEAACASVHG ANRLGANSLL DLVVFGRACA LSIAESCRPG DKVPPIKANA 

       490        500        510        520        530        540 
GEESVMNLDK LRFADGSVRT SELRLSMQKS MQSHAAVFRV GSVLQEGCEK VSQLYGDLQH 

       550        560        570        580        590        600 
LKTFDRGMVW NTDLVETLEL QNLMLCALQT IYGAEARKES RGAHAREDYK VRIDEYDYSK 

       610        620        630        640        650 
PIEGQQKKPF AEHWRKHTLS YVDTKTGKVT LDYRPVIDKT LNEADCATVP PAIRSY

Q920L2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools