NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).

[2]

IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
DOI=10.1016/S0092-8674(03)00926-7; PubMed=14651853 [NCBI, ExPASy, EBI, Israel, Japan]
Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M., Patterson N., Lander E.S., Mann M.;
"Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.";
Cell 115:629-640(2003).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC006727; AAH06727.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_659044.1; -.

UniGene

Mm.127731

3D structure databases

SMR

Q922W5; 1-275.

ModBase

Q922W5.

Protein-protein interaction databases

IntAct

Q922W5; -.

Organism-specific databases

MGI

MGI:2384795; Pycr1.

Gene expression databases

ArrayExpress

Q922W5; -.

CleanEx

MM_PYCR1; -.

GermOnline

ENSMUSG00000025140; Mus musculus.

Ontologies

GO:0005739;	Cellular component: mitochondrion (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

Ensembl

ENSMUSG00000025140; Mus musculus. [Contig view]

GeneID

209027; -.

KEGG

mmu:209027; -.

NMPDR

fig|10090.3.peg.25811; -.

Phylogenomic databases

HOGENOM

Q922W5; -.

HOVERGEN

Q922W5; -.

Other

Pycr1; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Mitochondrion; NADP; Oxidoreductase; Proline biosynthesis; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 26`	`26`	`Mitochondrion (Potential).`
`CHAIN`	`27 309`	`283`	`Pyrroline-5-carboxylate reductase 1, mitochondrial.`	`PRO_0000187315`

Sequence information

Length: 309 AA [This is the length of the unprocessed precursor]

Molecular weight: 32373 Da [This is the MW of the unprocessed precursor]

CRC64: A3CD24AACDD53DEF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDQA TVSALRKIGV NLTPHNKETV 

        70         80         90        100        110        120 
RHSDVLFLAV KPHIIPFILD EIGANIEDRH IVVSCAAGVT INSIEKKLTA FQPAPKVIRC 

       130        140        150        160        170        180 
MTNTPVVVRE GVTVYATGTH AQVEDGRLVE QLMGSVGFCT EVEEDLIDAV TGLSGSGPAY 

       190        200        210        220        230        240 
AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLDS EQHPSQLKDN VCSPGGATIH 

       250        260        270        280        290        300 
ALHVLESGGF RSLLINAVEA SCIRTRELQT MADQETISPA AIKKTVLDKV KLDSSAGASL 


SSDHVKPLP

Q922W5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools