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UniProtKB/Swiss-Prot entry Q9A5V1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_CAUCR
Primary accession number Q9A5V1
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 46)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: CC_2346
From
Caulobacter crescentus (Caulobacter vibrioides) [TaxID: 155892] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 19089 / CB15;
DOI=10.1073/pnas.061029298; PubMed=11259647 [NCBI, ExPASy, EBI, Israel, Japan]
Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E., Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R., Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B., DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R., Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O., Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
"Complete genome sequence of Caulobacter crescentus.";
Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE005673; AAK24317.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A87540; A87540.
RefSeq NP_421149.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q9A5V1.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q9A5V1.
Genome annotation databases
GeneID 943550; -.
GenomeReviews AE005673_GR; CC_2346.
KEGG ccr:CC_2346; -.
NMPDR fig|190650.1.peg.2329; -.
TIGR CC_2346; -.
Phylogenomic databases
HOGENOM Q9A5V1; -.
Other
ProtoNet Q9A5V1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Histidinol dehydrogenase. PRO_0000135753
ACT_SITE   323   323        Proton acceptor (By similarity). 
ACT_SITE   324   324        Proton acceptor (By similarity). 
METAL   256   256        Zinc (By similarity). 
METAL   259   259        Zinc (By similarity). 
METAL   357   357        Zinc (By similarity). 
METAL   416   416        Zinc (By similarity). 
BINDING   129   129        NAD (By similarity). 
BINDING   188   188        NAD (By similarity). 
BINDING   211   211        NAD (By similarity). 
BINDING   234   234        Substrate (By similarity). 
BINDING   256   256        Substrate (By similarity). 
BINDING   259   259        Substrate (By similarity). 
BINDING   324   324        Substrate (By similarity). 
BINDING   357   357        Substrate (By similarity). 
BINDING   411   411        Substrate (By similarity). 
BINDING   416   416        Substrate (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 45154 Da [This is the MW of the unprocessed precursor] CRC64: 89F4ECF58D67F2F2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRRFLFSDPD FQTAFKAFLD ERRGSPADVD AAVAGVLEAV RTQGIEALLD YSRRFDKVDL 

        70         80         90        100        110        120 
TAETIRVTAE EIEAGAAETP ADVREAIAFA AARIRAYHSR QRPADQAWTD EAGVELGWRW 

       130        140        150        160        170        180 
TPLEAVGVYV PGGRAAYPST VLMNAVPAQV AGVDRIAMVT PPGKLQPAVL AAAKEAGVTE 

       190        200        210        220        230        240 
IWRVGGAQAV AALAYGAGPI QPVDKIVGPG NAYVTAAKRR LYGVVGIDAL AGPSEIVVVA 

       250        260        270        280        290        300 
DNKNNPDWIA ADLLSQAEHD PAAQSILITD DEAFAAAVEQ AIAERLKTLA TGEDAAASWR 

       310        320        330        340        350        360 
DHGAVIIAPL DESPALVDAI APEHVEFALD NPERLSDRVR HAGAIFLGRV TPEAIGDYVA 

       370        380        390        400        410        420 
GSNHVLPTSR AARFQSGLSI YDFIKRTSIV KCDPASFAVL GPHTVALAKA EGLPAHALSA 


SVRLPSGD
Q9A5V1 in FASTA format

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