[1]
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NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION, AND VARIANT MET-266.
DOI=10.1042/0264-6021:3460603; PubMed=10698685 [NCBI, ExPASy, EBI, Israel, Japan]
Kim I.,
Kim H.-G.,
Kim H.,
Kim H.-H.,
Park S.K.,
Uhm C.-S.,
Lee Z.H.,
Koh G.Y.;
"Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis.";
Biochem. J. 346:603-610(2000).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND POSSIBLE FUNCTION.
TISSUE=Aortic endothelium;
DOI=10.1128/MCB.20.14.5343-5349.2000; PubMed=10866690 [NCBI, ExPASy, EBI, Israel, Japan]
Yoon J.C.,
Chickering T.W.,
Rosen E.D.,
Dussault B.,
Qin Y.,
Soukas A.,
Friedman J.M.,
Holmes W.E.,
Spiegelman B.M.;
"Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.";
Mol. Cell. Biol. 20:5343-5349(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=11953136 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu H.,
Li J.,
Qin W.,
Yang Y.,
He X.,
Wan D.,
Gu J.;
"Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis.";
Zhonghua Yi Xue Za Zhi 82:94-99(2002).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Placenta;
PubMed=14583458 [NCBI, ExPASy, EBI, Israel, Japan]
Ito Y.,
Oike Y.,
Yasunaga K.,
Hamada K.,
Miyata K.,
Matsumoto S.,
Sugano S.,
Tanihara H.,
Masuho Y.,
Suda T.;
"Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.";
Cancer Res. 63:6651-6657(2003).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Hair follicle dermal papilla;
Kim M.K.,
Kim Y.H.,
Seo J.M.,
Lee H.M.,
Chung H.J.,
Sohn M.Y.,
Hwang S.Y.,
Im S.U.,
Jung E.J.,
Lee J.H.,
Kim J.C.;
"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F.,
Gurney A.L.,
Abaya E.,
Baker K.,
Baldwin D.T.,
Brush J.,
Chen J.,
Chow B.,
Chui C.,
Crowley C.,
Currell B.,
Deuel B.,
Dowd P.,
Eaton D.,
Foster J.S.,
Grimaldi C.,
Gu Q.,
Hass P.E.,
Heldens S., ![]()
Huang A.,
Kim H.S.,
Klimowski L.,
Jin Y.,
Johnson S.,
Lee J.,
Lewis L.,
Liao D.,
Mark M.R.,
Robbie E.,
Sanchez C.,
Schoenfeld J.,
Seshagiri S.,
Simmons L.,
Singh J.,
Smith V.,
Stinson J.,
Vagts A.,
Vandlen R.L.,
Watanabe C.,
Wieand D.,
Woods K.,
Xie M.-H.,
Yansura D.G.,
Yi S.,
Yu G.,
Yuan J.,
Zhang M.,
Zhang Z.,
Goddard A.D.,
Wood W.I.,
Godowski P.J.,
Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-266.
TISSUE=Adipose tissue;
Suzuki Y.,
Sugano S.,
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[9]
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FUNCTION, AND TISSUE SPECIFICITY.
PubMed=12015030 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu H.,
Li J.,
Wan D.,
Yang Y.,
Qin W.,
Ge C.,
Yao M.,
Gu J.;
"Expression and function of hepatocellular carcinoma-related gene pp1158.";
Zhonghua Zhong Liu Za Zhi 24:123-125(2002).
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[10]
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DISEASE.
PubMed=12707035 [NCBI, ExPASy, EBI, Israel, Japan]
Le Jan S.,
Amy C.,
Cazes A.,
Monnot C.,
Lamande N.,
Favier J.,
Philippe J.,
Sibony M.,
Gasc J.-M.,
Corvol P.,
Germain S.;
"Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma.";
Am. J. Pathol. 162:1521-1528(2003).
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[11]
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DISEASE.
DOI=10.1016/j.clim.2004.12.002; PubMed=15870027 [NCBI, ExPASy, EBI, Israel, Japan]
Hermann L.M.,
Pinkerton M.,
Jennings K.,
Yang L.,
Grom A.,
Sowders D.,
Kersten S.,
Witte D.P.,
Hirsch R.,
Thornton S.;
"Angiopoietin-like-4 is a potential angiogenic mediator in arthritis.";
Clin. Immunol. 115:93-101(2005).
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[12]
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POSSIBLE INVOLVEMENT IN DIABETES TYPE 2.
DOI=10.1073/pnas.0408452102; PubMed=15837923 [NCBI, ExPASy, EBI, Israel, Japan]
Xu A.,
Lam M.C.,
Chan K.W.,
Wang Y.,
Zhang J.,
Hoo R.L.,
Xu J.Y.,
Chen B.,
Chow W.S.,
Tso A.W.,
Lam K.S.;
"Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.";
Proc. Natl. Acad. Sci. U.S.A. 102:6086-6091(2005).
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[13]
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VARIANTS LEU-5; LYS-40; ILE-41; ARG-67; LEU-72; ARG-77; LYS-167; SER-174; GLN-190; LYS-196; CYS-230; ARG-233; VAL-237; THR-251; MET-266; GLN-278; MET-291; MET-293; VAL-296; SER-307; MET-308; CYS-336; GLU-338; CYS-349; SER-361; ARG-361; GLN-371 AND TRP-384.
DOI=10.1038/ng1984; PubMed=17322881 [NCBI, ExPASy, EBI, Israel, Japan]
Romeo S.,
Pennacchio L.A.,
Fu Y.,
Boerwinkle E.,
Tybjaerg-Hansen A.,
Hobbs H.H.,
Cohen J.C.;
"Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.";
Nat. Genet. 39:513-516(2007).
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