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UniProtKB/Swiss-Prot entry Q9CBW1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DYR_MYCLE
Primary accession number Q9CBW1
Secondary accession numbers None
Integrated into Swiss-Prot on August 29, 2001
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 37)
Name and origin of the protein
Protein name Dihydrofolate reductase
Synonym EC 1.5.1.3
Gene name
Name: folA
OrderedLocusNames: ML1518
From
Mycobacterium leprae [TaxID: 1769] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TN;
DOI=10.1038/35059006; PubMed=11234002 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.;
"Massive gene decay in the leprosy bacillus.";
Nature 409:1007-1011(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL583922; CAC30469.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H87098; H87098.
RefSeq NP_302063.1; -.
3D structure databases
HSSP O33305; 1DF7. [HSSP ENTRY / PDB]
SMR Q9CBW1; 3-165.
ModBase Q9CBW1.
Enzyme and pathway databases
BioCyc MLEP272631:ML1518-MON; -.
Organism-specific databases
Leproma ML1518; -.
Family and domain databases
InterPro IPR012259; DHFR.
IPR001796; DHFR_reg.
Graphical view of domain structure.
PANTHER PTHR11549:SF1; DHFR; 1.
Pfam PF00186; DHFR_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00070; DHFR.
PROSITE PS00075; DHFR_1; 1.
PS51330; DHFR_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9CBW1.
Genome annotation databases
GeneID 909551; -.
GenomeReviews AL450380_GR; ML1518.
KEGG mle:ML1518; -.
NMPDR fig|272631.1.peg.935; -.
Phylogenomic databases
HOGENOM Q9CBW1; -.
Genome annotation databases
CMR Q9CBW1; ML1518.
Other
ProtoNet Q9CBW1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; One-carbon metabolism; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom To Length Description FTId
CHAIN   1   165  165     Dihydrofolate reductase. PRO_0000186399
DOMAIN   3   165  163     DHFR. 
Sequence information
Length: 165 AA [This is the length of the unprocessed precursor] Molecular weight: 18509 Da [This is the MW of the unprocessed precursor] CRC64: E6A76965BFBEC74F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTVVGLIWAQ STTGVIGRDG GMPWRVPEDL TRFKQLTMGH PVVMGRRTWD SLPVGVRPLP 

        70         80         90        100        110        120 
GRRNIVLSRQ IDFMAEGAEV FGSLEETISN LETEPEMWVI GGEQIYRLAL PLATRCGVTE 

       130        140        150        160 
VDTYLLHEDD DVLAPVLDDT WVGVTGEWLV SCSGLRYRLH SYHRS 

Q9CBW1 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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