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UniProtKB/Swiss-Prot entry Q9CQA3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHSB_MOUSE
Primary accession number Q9CQA3
Secondary accession numbers Q3TF82 Q9DC91
Integrated into Swiss-Prot on August 31, 2004
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [Precursor]
Synonyms EC 1.3.5.1
Iron-sulfur subunit of complex II
Ip
Gene name
Name: Sdhb
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Amnion, Bone marrow, Brain, and Tongue;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6, and FVB/N;
TISSUE=Brain, and Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 49-92; 118-125; 129-153; 170-179; 208-232 AND 245-257, AND MASS SPECTROMETRY.
STRAIN=C57BL/6;
TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK003052; BAB22534.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK003533; BAB22842.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK009660; BAB26422.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK153045; BAE31674.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169252; BAE41016.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013509; AAH13509.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051934; AAH51934.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR PT0094; PT0094.
RefSeq NP_075863.2; -.
UniGene Mm.246965
3D structure databases
HSSP P07014; 1NEK. [HSSP ENTRY / PDB]
SMR Q9CQA3; 39-277.
ModBase Q9CQA3.
Protein-protein interaction databases
IntAct Q9CQA3; -.
2D gel databases
REPRODUCTION-2DPAGE Q9CQA3; -.
Organism-specific databases
MGI MGI:1914930; Sdhb.
Gene expression databases
ArrayExpress Q9CQA3; -.
GermOnline ENSMUSG00000009863; Mus musculus.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.
Gene3D G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam PF00111; Fer2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00384; dhsB; 1.
PROSITE PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9CQA3.
Genome annotation databases
Ensembl ENSMUSG00000009863; Mus musculus. [Contig view]
GeneID 67680; -.
KEGG mmu:67680; -.
NMPDR fig|10090.3.peg.10709; -.
Phylogenomic databases
HOGENOM Q9CQA3; -.
HOVERGEN Q9CQA3; -.
Other
SOURCE Sdhb; Mus musculus.
ProtoNet Q9CQA3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; 3Fe-4S; 4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    30  30     Mitochondrion (By similarity). 
CHAIN   31   282  252     Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial. PRO_0000010356
DOMAIN   42   135  94     2Fe-2S ferredoxin-type. 
DOMAIN   178   208  31     4Fe-4S ferredoxin-type. 
METAL   95    95        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   100   100        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   103   103        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   115   115        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   188   188        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   191   191        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   194   194        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   198   198        Iron-sulfur 3 (3Fe-4S) (By similarity). 
METAL   245   245        Iron-sulfur 3 (3Fe-4S) (By similarity). 
METAL   251   251        Iron-sulfur 3 (3Fe-4S) (By similarity). 
METAL   255   255        Iron-sulfur 2 (4Fe-4S) (By similarity). 
BINDING   203   203        Ubiquinone; shared with DHSD (By similarity). 
CONFLICT   40    40        R -> K (in Ref. 1; BAB22534). 
Sequence information
Length: 282 AA [This is the length of the unprocessed precursor] Molecular weight: 31814 Da [This is the MW of the unprocessed precursor] CRC64: A8616A911427AF8E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAATVGVSLK RGFPAAVLGR VGLQFQACRG AQTAAAAAPR IKKFAIYRWD PDKTGDKPRM 

        70         80         90        100        110        120 
QTYEVDLNKC GPMVLDALIK IKNEVDSTLT FRRSCREGIC GSCAMNINGG NTLACTRRID 

       130        140        150        160        170        180 
TDLSKVSKIY PLPHMYVIKD LVPDLSNFYA QYKSIEPYLK KKDESQEGKQ QYLQSIEDRE 

       190        200        210        220        230        240 
KLDGLYECIL CACCSTSCPS YWWNGDKYLG PAVLMQAYRW MIDSRDDFTE ERLAKLQDPF 

       250        260        270        280 
SVYRCHTIMN CTQTCPKGLN PGKAIAEIKK MMATYKEKRA LA 

Q9CQA3 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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