ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q9I0K1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name NUOA_PSEAE
Primary accession number Q9I0K1
Secondary accession numbers None
Integrated into Swiss-Prot on May 15, 2007
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit A
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit A
NDH-1 subunit A
Gene name
Name: nuoA
OrderedLocusNames: PA2637
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SUBUNIT: Composed of 13 different subunits. Subunits nuoA, H, J, K, L, M, N constitute the membrane sector of the complex (By similarity).
  • SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
  • SIMILARITY: Belongs to the complex I subunit 3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004091; AAG06025.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B83316; B83316.
RefSeq NP_251327.1; -.
3D structure databases
ModBase Q9I0K1.
Enzyme and pathway databases
BioCyc PAER208964:PA2637-MON; -.
Organism-specific databases
PseudoCAP PA2637; -.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR000440; Oxidored_q4.
Graphical view of domain structure.
PANTHER PTHR11058; Oxidored_q4; 1.
Pfam PF00507; Oxidored_q4; 1.
Pfam graphical view of domain structure.
BLOCKS Q9I0K1.
Genome annotation databases
GeneID 882344; -.
GenomeReviews AE004091_GR; PA2637.
KEGG pae:PA2637; -.
Phylogenomic databases
HOGENOM Q9I0K1; -.
Genome annotation databases
CMR Q9I0K1; PA2637.
Other
ProtoNet Q9I0K1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase; Quinone; Transmembrane; Ubiquinone.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   137  137     NADH-quinone oxidoreductase subunit A. PRO_0000287834
TRANSMEM   12    32  21     Potential. 
TRANSMEM   66    86  21     Potential. 
TRANSMEM   95   115  21     Potential. 
Sequence information
Length: 137 AA [This is the length of the unprocessed precursor] Molecular weight: 15010 Da [This is the MW of the unprocessed precursor] CRC64: AACE0C233E45AA83 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPNPAELAAH HWGFAAFLLG VVGLLAFMLG VSSLLGSKAF GRSKNEPFES GIVPTGGARL 

        70         80         90        100        110        120 
RLSAKFYLVA MLFVIFDVEA LFLFAWSVSV RESGWAGLIE ATIFIAILLA GLVYLWRIGA 

       130 
LDWAPESRRK RQAKLKQ 

Q9I0K1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!