ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q9I1C2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name MSUD_PSEAE
Primary accession number Q9I1C2
Secondary accession number O31039
Integrated into Swiss-Prot on January 10, 2003
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Methanesulfonate monooxygenase
Synonyms EC 1.14.14.5
Methanesulfonate sulfonatase
FMNH2-dependent methanesulfonate monooxygenase
Gene name
Name: msuD
OrderedLocusNames: PA2356
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
PubMed=10049377 [NCBI, ExPASy, EBI, Israel, Japan]
Kertesz M.A., Schmidt-Larbig K., Wueest T.;
"A novel reduced flavin mononucleotide-dependent methanesulfonate sulfonatase encoded by the sulfur-regulated msu operon of Pseudomonas aeruginosa.";
J. Bacteriol. 181:1464-1473(1999).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
Comments
  • FUNCTION: Catalyzes the desulfonation of aliphatic sulfonates. Shows highest activity with methanesulfonate.
  • CATALYTIC ACTIVITY: An alkanesufonate (R-CH2-SO3H) + FMNH2 + O2 = an aldehyde (R-CHO) + FMN + sulfite + H2O.
  • INDUCTION: Repressed by sulfate, cysteine, or thiocyanate.
  • MISCELLANEOUS: FMNH(2) which is absolutely required for this enzymatic reaction, is provided by msuE.
  • SIMILARITY: Belongs to the ssuD family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF026067; AAB82564.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE004091; AAG05744.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E83352; E83352.
RefSeq NP_251046.1; -.
3D structure databases
HSSP P80645; 1M41. [HSSP ENTRY / PDB]
SMR Q9I1C2; 1-347.
ModBase Q9I1C2.
Enzyme and pathway databases
BioCyc PAER208964:PA2356-MON; -.
Organism-specific databases
PseudoCAP PA2356; -.
Ontologies
GO
GO:0008726; Molecular function: alkanesulfonate monooxygenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01229; -; 1.
PBIL [Tree]
InterPro IPR011251; Luciferase-like_bac.
IPR016048; Luciferase_mOase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.30; Luciferase_like; 1.
Pfam PF00296; Bac_luciferase; 1.
Pfam graphical view of domain structure.
BLOCKS Q9I1C2.
Genome annotation databases
GeneID 879651; -.
GenomeReviews AE004091_GR; PA2356.
KEGG pae:PA2356; -.
Phylogenomic databases
HOGENOM Q9I1C2; -.
Genome annotation databases
CMR Q9I1C2; PA2356.
Other
ProtoNet Q9I1C2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FMN; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   381  381     Methanesulfonate monooxygenase. PRO_0000216710
CONFLICT   28    28        P -> S (in Ref. 1; AAB82564). 
Sequence information
Length: 381 AA [This is the length of the unprocessed precursor] Molecular weight: 41596 Da [This is the MW of the unprocessed precursor] CRC64: F39FF1C2E3217747 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNVFWFLPTH GDGHFLGTSQ GARPVSLPYL KQVAQAADSL GYHGVLIPTG RSCEDSWVVA 

        70         80         90        100        110        120 
SALAPLTERL RFLVAIRPGI VSPTVSARMA ATLDRLSGGR LLINVVTGGD PDENRGDGIH 

       130        140        150        160        170        180 
LGHAERYEVT DEFLRVWRRV LQGEAVDFHG KHIHVENAKA LYPPLQRPYP PLYFGGSSEA 

       190        200        210        220        230        240 
AHELAGEQVD VYLTWGEPLP AVAAKIADVR QRAARHGRTV KFGIRLHVIV RETAEEAWRA 

       250        260        270        280        290        300 
ADRLIEHISD ETIAAAQQSF ARFDSEGQRR MAALHGGRRD RLEIQPNLWA GVGLVRGGAG 

       310        320        330        340        350        360 
TALVGDPRQV AERIGEYAEL GIDSFIFSGY PHLEEAYRFA ELVFPLLPEP YASLAGRGLT 

       370        380 
NLTGPFGEMI ANDVLPARAG A
Q9I1C2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!