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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K.,
Pham X.-Q.T.,
Erwin A.L.,
Mizoguchi S.D.,
Warrener P.,
Hickey M.J.,
Brinkman F.S.L.,
Hufnagle W.O.,
Kowalik D.J.,
Lagrou M.,
Garber R.L.,
Goltry L.,
Tolentino E.,
Westbrock-Wadman S.,
Yuan Y.,
Brody L.L.,
Coulter S.N.,
Folger K.R.,
Kas A., ![]()
Larbig K.,
Lim R.M.,
Smith K.A.,
Spencer D.H.,
Wong G.K.-S.,
Wu Z.,
Paulsen I.T.,
Reizer J.,
Saier M.H. Jr.,
Hancock R.E.W.,
Lory S.,
Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
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[2]
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FUNCTION.
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1073/pnas.0307308101; PubMed=14766977 [NCBI, ExPASy, EBI, Israel, Japan]
Vance R.E.,
Hong S.,
Gronert K.,
Serhan C.N.,
Mekalanos J.J.;
"The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.";
Proc. Natl. Acad. Sci. U.S.A. 101:2135-2139(2004).
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- FUNCTION: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.aeruginosa infections.
- CATALYTIC ACTIVITY: Arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
- COFACTOR: Binds 1 iron ion per subunit (By similarity).
- SUBCELLULAR LOCATION: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu.
- SIMILARITY: Belongs to the lipoxygenase family.
- SIMILARITY: Contains 1 lipoxygenase domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 685 AA [This is the length of the unprocessed precursor] |
Molecular weight: 74804 Da [This is the MW of the unprocessed precursor] |
CRC64: B6A307595AE16A5E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MKRRSVLLSG VALSGTALAN DSIFFSPLKY LGAEQQRSID ASRSLLDNLI PPSLPQYDNL
70 80 90 100 110 120
AGKLARRAVL TSKKLVYVWT ENFGNVKGVP MARSVPLGEL PNVDWLLKTA GVIVELIVNF
130 140 150 160 170 180
VASLPASAAA QFERIATGLS GDLEAARQVH EALLEEAKND PAAAGSLLLR FTELQTRVIA
190 200 210 220 230 240
ILTRVGLLVD DILKSASNLV TQRGQGDGLN RFRAVFGTLR LPEVADSFRD DEAFAYWRVA
250 260 270 280 290 300
GPNPLLIRRV DALPANFPLG EEQFRRVMGA DDSLLEAAAS RRLYLLDYAE LGKLAPSGAV
310 320 330 340 350 360
DKLLTGTGFA YAPIALFALG KDRARLLPVA IQCGQDPATH PMFVRPAESE SDLYWGWQMA
370 380 390 400 410 420
KTVVQVAEEN YHEMFVHLAQ THLVSEAFCL ATQRTLAPSH PLHVLLAPHF EGTLFINEGA
430 440 450 460 470 480
ARILLPSAGF IDVMFAAPIQ DTQATAGGNR LGFDFYRGML PESLKARNVD DPLALPDYPY
490 500 510 520 530 540
RDDGLLVWNA IRQWAADYVA VYYASDGDVT ADVELAAWVG EVIGSGKVAG FRPITGRSQL
550 560 570 580 590 600
VEVLTMVIFT ASAQHAAVNF PQPSMMTYAP AICAMSAAPA PDSPSGKSEA DWLKMMPPTL
610 620 630 640 650 660
VALEKVNIYH LLGSVYHGRL GDYRQTGFPY APVFSDRRVT ASGGPLERFQ ARLKEVEATI
670 680
RTRNQARRRP YEYLLPSRIP ASTNI
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Q9I4G8 in FASTA format |
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