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UniProtKB/Swiss-Prot entry Q9JS33

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYSI_NEIMB
Primary accession number Q9JS33
Secondary accession numbers None
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 36)
Name and origin of the protein
Protein name Sulfite reductase [NADPH] hemoprotein beta-component
Synonyms SIR-HP
SIRHP
EC 1.8.1.2
Gene names
Name: cysI1
Synonyms: cysI-1
OrderedLocusNames: NMB1151
and
Name: cysI2
Synonyms: cysI-2
OrderedLocusNames: NMB1189
From
Neisseria meningitidis serogroup B [TaxID: 491] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58 / Serogroup B;
DOI=10.1126/science.287.5459.1809; PubMed=10710307 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.";
Science 287:1809-1815(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE002098; AAF62325.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE002098; AAF62326.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_274179.1; -.
NP_274215.1; -.
3D structure databases
HSSP P17846; 7GEP. [HSSP ENTRY / PDB]
ModBase Q9JS33.
Enzyme and pathway databases
BioCyc NMEN122586:NMB_1151-MON; -.
NMEN122586:NMB_1189-MON; -.
Ontologies
GO
GO:0004783; Molecular function: sulfite reductase (NADPH) activity (inferred from electronic annotation from HAMAP).
GO:0000103; Biological process: sulfate assimilation (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01540; -; 1.
PBIL [Tree]
InterPro IPR011786; CysI.
IPR006066; Nir_Si_BS.
IPR006067; Nir_Sir_4Fe4S.
IPR005117; NiRdtase/SiRdtase_haem-b_fer.
Graphical view of domain structure.
Pfam PF01077; NIR_SIR; 1.
PF03460; NIR_SIR_ferr; 2.
Pfam graphical view of domain structure.
PRINTS PR00397; SIROHAEM.
TIGRFAMs TIGR02041; CysI; 1.
PROSITE PS00365; NIR_SIR; 1.
BLOCKS Q9JS33.
Genome annotation databases
GeneID 903572; -.
903609; -.
GenomeReviews AE002098_GR; NMB1151.
AE002098_GR; NMB1189.
KEGG nme:NMB1151; -.
nme:NMB1189; -.
TIGR NMB1151; -.
NMB1189; -.
Phylogenomic databases
HOGENOM Q9JS33; -.
Other
ProtoNet Q9JS33.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Heme; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   589  589     Sulfite reductase [NADPH] hemoprotein beta-component. PRO_0000199902
METAL   443   443        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   449   449        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   488   488        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   492   492        Iron (siroheme axial ligand) (By similarity). 
METAL   492   492        Iron-sulfur (4Fe-4S) (By similarity). 
Sequence information
Length: 589 AA [This is the length of the unprocessed precursor] Molecular weight: 65966 Da [This is the MW of the unprocessed precursor] CRC64: 4D79962B7B7B0339 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVQTKTKGL AWQEKPLSDN ERLKTESNFL RGTILDDLKD PLTGGFKGDN FQLIRFHGMY 

        70         80         90        100        110        120 
EQDDRDIRAE RAEAKLEPLK FMLLRCRLPG GIIKPSQWIE LDKFARENSH YRSIRLTNRQ 

       130        140        150        160        170        180 
TFQFHGVPKA KLQTMHRLLH KLGLDSIATA ADMNRNVLCT SNPIESELHR QAYEYAKKIS 

       190        200        210        220        230        240 
EHLLPRTRGY LDVWVDGKKV QSSDDFLQED EPILGKTYLP RKFKTAVVIP PLNDVDCYGN 

       250        260        270        280        290        300 
DLDFVAVSDG NGQLAGFNVL AGGGLSMEHG NTKTYPNISL ELGFVPPEHA LKAAEAVVTT 

       310        320        330        340        350        360 
QRDFGNRSDR KNARTRYTIQ NMGLDNFRAE VERRMGMPFE PVRPFKFTGR GDRIGWVKGI 

       370        380        390        400        410        420 
DGNWHLTLFI ESGRLVDEGG KQLLTGVLEI AKIHKGDFRI TANQNLIVAN VAEADKAKIE 

       430        440        450        460        470        480 
EFARTYGLIR NDVSKLRENA MSCVSFPTCP LAMAEAERVL PDFIGELDKI MAKHGTSDDY 

       490        500        510        520        530        540 
IVTRITGCPN GCGRAMLAEI GLVGKAVGRY NLHIGGDREG VRIPRLYKEN ITLPEILAEL 

       550        560        570        580 
DDLIGKWAAE RNIGEGFGDF AIRTGIVKPV LNAPVDFWDA SKAVAIARA
Q9JS33 in FASTA format

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