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UniProtKB/Swiss-Prot entry Q9JZQ3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name METF_NEIMB
Primary accession number Q9JZQ3
Secondary accession numbers None
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 40)
Name and origin of the protein
Protein name 5,10-methylenetetrahydrofolate reductase
Synonym EC 1.5.1.20
Gene name
Name: metF
OrderedLocusNames: NMB0943
From
Neisseria meningitidis serogroup B [TaxID: 491] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MC58 / Serogroup B;
DOI=10.1126/science.287.5459.1809; PubMed=10710307 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C.;
"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.";
Science 287:1809-1815(2000).
[2]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1002/pmic.200500821; PubMed=16645985 [NCBI, ExPASy, EBI, Israel, Japan]
Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.;
"Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254.";
Proteomics 6:3400-3413(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE002098; AAF41349.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D81140; D81140.
RefSeq NP_273981.1; -.
3D structure databases
HSSP P00394; 1B5T. [HSSP ENTRY / PDB]
SMR Q9JZQ3; 3-292.
ModBase Q9JZQ3.
Enzyme and pathway databases
BioCyc NMEN122586:NMB_0943-MON; -.
Family and domain databases
InterPro IPR003171; Mehydrof_redctse.
IPR004620; MTHF_reductase_bac.
Graphical view of domain structure.
Pfam PF02219; MTHFR; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00676; fadh2; 1.
BLOCKS Q9JZQ3.
Genome annotation databases
GeneID 903063; -.
GenomeReviews AE002098_GR; NMB0943.
KEGG nme:NMB0943; -.
NMPDR fig|122586.1.peg.915; -.
TIGR NMB0943; -.
Phylogenomic databases
HOGENOM Q9JZQ3; -.
Other
ProtoNet Q9JZQ3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; FAD; Flavoprotein; Methionine biosynthesis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   292  292     5,10-methylenetetrahydrofolate reductase. PRO_0000320271
Sequence information
Length: 292 AA [This is the length of the unprocessed precursor] Molecular weight: 33056 Da [This is the MW of the unprocessed precursor] CRC64: 32B22282A681CB1F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNYAKEINAL NNSLSDLKGD INVSFEFFPP KNEQMETMLW DSIHRLQTLH PKFVSVTYGA 

        70         80         90        100        110        120 
NSGERDRTHG IVKRIKQETG LEAAPHLTGI DASPDELRQI AKDYWDSGIR RIVALRGDEP 

       130        140        150        160        170        180 
AGYEKKPFYA EDLVKLLRSV ADFDISVAAY PEVHPEAKSA QADLINLKRK IDAGANHVIT 

       190        200        210        220        230        240 
QFFFDVERYL RFRDRCVMLG IDVEIVPGIL PVTNFKQLGK MAQVTNVKIP SWLSQMYEGL 

       250        260        270        280        290 
DDDQGTRNLV AASIAIDMVK VLSREGVKDF HFYTLNRSEL TYAICHILGV RP 

Q9JZQ3 in FASTA format

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