NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153;
DOI=10.1093/nar/28.21.4317; PubMed=11058132 [NCBI, ExPASy, EBI, Israel, Japan]
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.";
Nucleic Acids Res. 28:4317-4331(2000).

Comments

CATALYTIC ACTIVITY: (S)-dihydroorotate + O₂ = orotate + H₂O₂.
COFACTOR: Binds 1 FMN per subunit (By similarity).
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6 .
SUBUNIT: Heterotetramer of 2 pyrK and 2 pyrD subunits (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000004; BAB06253.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

F83966; F83966.

RefSeq

NP_243400.1; -.

3D structure databases

HSSP

P54322; 1EP2. [HSSP ENTRY / PDB]

ModBase

Q9K9W1.

Enzyme and pathway databases

BioCyc

BHAL272558:BH2534-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004158;	Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00224; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000164; DHO_oxidase; 1.

TIGRFAMs

TIGR01037; pyrD_sub1_fam; 1.

PROSITE

PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.

BLOCKS

Q9K9W1.

Genome annotation databases

891493; -.

BA000004_GR; BH2534.

bha:BH2534; -.

fig|272558.1.peg.2534; -.

Phylogenomic databases

HOGENOM

Q9K9W1; -.

Genome annotation databases

CMR

Q9K9W1; BH2534.

Other

ProtoNet

Q9K9W1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Flavoprotein; FMN; Oxidoreductase; Pyrimidine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 305`	`305`	`Dihydroorotate dehydrogenase.`	`PRO_0000148388`
`ACT_SITE`	`130 130`		`Nucleophile (By similarity).`

Sequence information

Length: 305 AA [This is the length of the unprocessed precursor]

Molecular weight: 32133 Da [This is the MW of the unprocessed precursor]

CRC64: 726B468AA5ECD726 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSRLAVELPG LSMKNPIMPA SGCFGFGKEF AGFYDLNHLG AIAIKATTVE PRFGNPTPRV 

        70         80         90        100        110        120 
AETHSGMLNA IGLQNPGLNN VIDNELARLA DVDVPIVANI AGSTVNDYVE VAEAISRVDN 

       130        140        150        160        170        180 
VHALELNISC PNVKEGGIAF GTVPDVAAQL TQEVKRVSTV PVYVKLSPNV SDIVEMAQAV 

       190        200        210        220        230        240 
ERAGADGLSM INTLLGMRLD LKRRTPILAN GTGGLSGPAI KPVAIRMIYQ VSQAVSIPII 

       250        260        270        280        290        300 
GMGGIQSADD VLEFMLAGAD AVAVGTANFT DPYVCPTIID ELPKRMDELG IERIADIVGG 


SWKQS

Q9K9W1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools