NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153;
DOI=10.1093/nar/28.21.4317; PubMed=11058132 [NCBI, ExPASy, EBI, Israel, Japan]
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.";
Nucleic Acids Res. 28:4317-4331(2000).

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000004; BAB05043.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D83815; D83815.

RefSeq

NP_242190.1; -.

3D structure databases

HSSP

Q58484; 1NVT. [HSSP ENTRY / PDB]

ModBase

Q9KD93.

Enzyme and pathway databases

BioCyc

BHAL272558:BH1324-MON; -.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

Q9KD93.

Genome annotation databases

892076; -.

BA000004_GR; BH1324.

bha:BH1324; -.

fig|272558.1.peg.1324; -.

Phylogenomic databases

HOGENOM

Q9KD93; -.

Genome annotation databases

CMR

Q9KD93; BH1324.

Other

ProtoNet

Q9KD93.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 278`	`278`	`Shikimate dehydrogenase.`	`PRO_0000135991`
`NP_BIND`	`127 131`	`5`	`NADP (By similarity).`

Sequence information

Length: 278 AA [This is the length of the unprocessed precursor]

Molecular weight: 30630 Da [This is the MW of the unprocessed precursor]

CRC64: 2000144C84686264 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKLFGLLGH PVGHSLSPLM HNQMFQLLDF DGYYHAFDVE PSQLEKAVEG ARALQMQGFN 

        70         80         90        100        110        120 
VTIPHKVTIM DYLDMVDEEA QEIGAVNTVV MKDGQLFGSN TDGQGYLESL MDVVTTPFPT 

       130        140        150        160        170        180 
QDVLIIGAGG AARAIGTVLK REKVRSITIA NRTLAKAEEF SGVLESSETS CSALSLKEAE 

       190        200        210        220        230        240 
QQLERFSVII NTTSVGMSPR VDDMPLSLER LSRETVVSDL IYNPLETKFL REAKQKGAKT 

       250        260        270 
VDGLGMFVNQ GALAFELWTG LRPDREKMRR CVLEQLGG

Q9KD93 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools