[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Leaf; PubMed=10353219 [NCBI, ExPASy, EBI, Israel, Japan] Ficarelli A., Tassi F., Restivo F.M.; "Isolation and characterization of two cDNA clones encoding for glutamate dehydrogenase in Nicotiana plumbaginifolia."; Plant Cell Physiol. 40:339-342(1999).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. TISSUE=Leaf; Restivo F.M., Panizzi N., De Monte G., Ficarelli A.; "Genomic organisation of GDH genes in Nicotiana plumbaginifolia."; Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-glutamate + H₂O + NAD(P)⁺ = 2-oxoglutarate + NH₃ + NAD(P)H.
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Y08293; CAA69601.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ277950; CAB94837.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T16982; T16982.

3D structure databases

HSSP

P96110; 1B26. [HSSP ENTRY / PDB]

ModBase

Q9LEC8.

Ontologies

GO:0004353;	Molecular function: glutamate dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11606:SF2; GLFV_DH; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000185; Glu_DH; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 411`	`411`	`Glutamate dehydrogenase B.`	`PRO_0000182751`
`ACT_SITE`	`102 102`		`By similarity.`
`CONFLICT`	`92 92`		`A -> R (in Ref. 1; CAA69601).`
`CONFLICT`	`368 368`		`A -> D (in Ref. 1; CAA69601).`

Sequence information

Length: 411 AA [This is the length of the unprocessed precursor]

Molecular weight: 44508 Da [This is the MW of the unprocessed precursor]

CRC64: 236D4915B8B670AE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNALAATNRN FKLASRLLGL DSKLEQCLLI PFREIKVECT IPKDDGSLAT FIGFRVQHDN 

        70         80         90        100        110        120 
ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVANIPYGG AKGGIGCSPS DLSISELERL 

       130        140        150        160        170        180 
TRVFTQKIHD LIGVHTDVPA PDMGTNPQTM AWILDEYSKF HGYSPAVVTG KPIDLGGSLG 

       190        200        210        220        230        240 
RDAATGRGVL FAAEALLRDH GKSIAGQRFV VQGFGNVGSW AAQLITEQGG KIVAVSDITG 

       250        260        270        280        290        300 
AIKNKNGIDI ASLLKHVKEN RGVKGFHGAD SIDPNSILVE DCDVLIPAAL GGVINRDNAK 

       310        320        330        340        350        360 
DIKAKFIVEA ANHPTDPEAD EILAKKGVVI LPDIYANSGG VTVSYFEWVQ NIQGFMWDEE 

       370        380        390        400        410 
RVNTELKAYM NRGFKDVKDM CKTHNCDLRM GAFTLGVNRV ARATTLRGWE A

Q9LEC8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools